Nature Communications (Jun 2021)
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- Itziar de Rojas,
- Sonia Moreno-Grau,
- Niccolo Tesi,
- Benjamin Grenier-Boley,
- Victor Andrade,
- Iris E. Jansen,
- Nancy L. Pedersen,
- Najada Stringa,
- Anna Zettergren,
- Isabel Hernández,
- Laura Montrreal,
- Carmen Antúnez,
- Anna Antonell,
- Rick M. Tankard,
- Joshua C. Bis,
- Rebecca Sims,
- Céline Bellenguez,
- Inés Quintela,
- Antonio González-Perez,
- Miguel Calero,
- Emilio Franco-Macías,
- Juan Macías,
- Rafael Blesa,
- Laura Cervera-Carles,
- Manuel Menéndez-González,
- Ana Frank-García,
- Jose Luís Royo,
- Fermin Moreno,
- Raquel Huerto Vilas,
- Miquel Baquero,
- Mónica Diez-Fairen,
- Carmen Lage,
- Sebastián García-Madrona,
- Pablo García-González,
- Emilio Alarcón-Martín,
- Sergi Valero,
- Oscar Sotolongo-Grau,
- Abbe Ullgren,
- Adam C. Naj,
- Afina W. Lemstra,
- Alba Benaque,
- Alba Pérez-Cordón,
- Alberto Benussi,
- Alberto Rábano,
- Alessandro Padovani,
- Alessio Squassina,
- Alexandre de Mendonça,
- Alfonso Arias Pastor,
- Almar A. L. Kok,
- Alun Meggy,
- Ana Belén Pastor,
- Ana Espinosa,
- Anaïs Corma-Gómez,
- Angel Martín Montes,
- Ángela Sanabria,
- Anita L. DeStefano,
- Anja Schneider,
- Annakaisa Haapasalo,
- Anne Kinhult Ståhlbom,
- Anne Tybjærg-Hansen,
- Annette M. Hartmann,
- Annika Spottke,
- Arturo Corbatón-Anchuelo,
- Arvid Rongve,
- Barbara Borroni,
- Beatrice Arosio,
- Benedetta Nacmias,
- Børge G. Nordestgaard,
- Brian W. Kunkle,
- Camille Charbonnier,
- Carla Abdelnour,
- Carlo Masullo,
- Carmen Martínez Rodríguez,
- Carmen Muñoz-Fernandez,
- Carole Dufouil,
- Caroline Graff,
- Catarina B. Ferreira,
- Caterina Chillotti,
- Chandra A. Reynolds,
- Chiara Fenoglio,
- Christine Van Broeckhoven,
- Christopher Clark,
- Claudia Pisanu,
- Claudia L. Satizabal,
- Clive Holmes,
- Dolores Buiza-Rueda,
- Dag Aarsland,
- Dan Rujescu,
- Daniel Alcolea,
- Daniela Galimberti,
- David Wallon,
- Davide Seripa,
- Edna Grünblatt,
- Efthimios Dardiotis,
- Emrah Düzel,
- Elio Scarpini,
- Elisa Conti,
- Elisa Rubino,
- Ellen Gelpi,
- Eloy Rodriguez-Rodriguez,
- Emmanuelle Duron,
- Eric Boerwinkle,
- Evelyn Ferri,
- Fabrizio Tagliavini,
- Fahri Küçükali,
- Florence Pasquier,
- Florentino Sanchez-Garcia,
- Francesca Mangialasche,
- Frank Jessen,
- Gaël Nicolas,
- Geir Selbæk,
- Gemma Ortega,
- Geneviève Chêne,
- Georgios Hadjigeorgiou,
- Giacomina Rossi,
- Gianfranco Spalletta,
- Giorgio Giaccone,
- Giulia Grande,
- Giuliano Binetti,
- Goran Papenberg,
- Harald Hampel,
- Henri Bailly,
- Henrik Zetterberg,
- Hilkka Soininen,
- Ida K. Karlsson,
- Ignacio Alvarez,
- Ildebrando Appollonio,
- Ina Giegling,
- Ingmar Skoog,
- Ingvild Saltvedt,
- Innocenzo Rainero,
- Irene Rosas Allende,
- Jakub Hort,
- Janine Diehl-Schmid,
- Jasper Van Dongen,
- Jean-Sebastien Vidal,
- Jenni Lehtisalo,
- Jens Wiltfang,
- Jesper Qvist Thomassen,
- Johannes Kornhuber,
- Jonathan L. Haines,
- Jonathan Vogelgsang,
- Juan A. Pineda,
- Juan Fortea,
- Julius Popp,
- Jürgen Deckert,
- Katharina Buerger,
- Kevin Morgan,
- Klaus Fließbach,
- Kristel Sleegers,
- Laura Molina-Porcel,
- Lena Kilander,
- Leonie Weinhold,
- Lindsay A. Farrer,
- Li-San Wang,
- Luca Kleineidam,
- Lucia Farotti,
- Lucilla Parnetti,
- Lucio Tremolizzo,
- Lucrezia Hausner,
- Luisa Benussi,
- Lutz Froelich,
- M. Arfan Ikram,
- M. Candida Deniz-Naranjo,
- Magda Tsolaki,
- Maitée Rosende-Roca,
- Malin Löwenmark,
- Marc Hulsman,
- Marco Spallazzi,
- Margaret A. Pericak-Vance,
- Margaret Esiri,
- María Bernal Sánchez-Arjona,
- Maria Carolina Dalmasso,
- María Teresa Martínez-Larrad,
- Marina Arcaro,
- Markus M. Nöthen,
- Marta Fernández-Fuertes,
- Martin Dichgans,
- Martin Ingelsson,
- Martin J. Herrmann,
- Martin Scherer,
- Martin Vyhnalek,
- Mary H. Kosmidis,
- Mary Yannakoulia,
- Matthias Schmid,
- Michael Ewers,
- Michael T. Heneka,
- Michael Wagner,
- Michela Scamosci,
- Miia Kivipelto,
- Mikko Hiltunen,
- Miren Zulaica,
- Montserrat Alegret,
- Myriam Fornage,
- Natalia Roberto,
- Natasja M. van Schoor,
- Nazib M. Seidu,
- Nerisa Banaj,
- Nicola J. Armstrong,
- Nikolaos Scarmeas,
- Norbert Scherbaum,
- Oliver Goldhardt,
- Oliver Hanon,
- Oliver Peters,
- Olivia Anna Skrobot,
- Olivier Quenez,
- Ondrej Lerch,
- Paola Bossù,
- Paolo Caffarra,
- Paolo Dionigi Rossi,
- Paraskevi Sakka,
- Per Hoffmann,
- Peter A. Holmans,
- Peter Fischer,
- Peter Riederer,
- Qiong Yang,
- Rachel Marshall,
- Rajesh N. Kalaria,
- Richard Mayeux,
- Rik Vandenberghe,
- Roberta Cecchetti,
- Roberta Ghidoni,
- Ruth Frikke-Schmidt,
- Sandro Sorbi,
- Sara Hägg,
- Sebastiaan Engelborghs,
- Seppo Helisalmi,
- Sigrid Botne Sando,
- Silke Kern,
- Silvana Archetti,
- Silvia Boschi,
- Silvia Fostinelli,
- Silvia Gil,
- Silvia Mendoza,
- Simon Mead,
- Simona Ciccone,
- Srdjan Djurovic,
- Stefanie Heilmann-Heimbach,
- Steffi Riedel-Heller,
- Teemu Kuulasmaa,
- Teodoro del Ser,
- Thibaud Lebouvier,
- Thomas Polak,
- Tiia Ngandu,
- Timo Grimmer,
- Valentina Bessi,
- Valentina Escott-Price,
- Vilmantas Giedraitis,
- Vincent Deramecourt,
- Wolfgang Maier,
- Xueqiu Jian,
- Yolande A. L. Pijnenburg,
- EADB contributors,
- The GR@ACE study group,
- DEGESCO consortium,
- IGAP (ADGC, CHARGE, EADI, GERAD),
- PGC-ALZ consortia,
- Patrick Gavin Kehoe,
- Guillermo Garcia-Ribas,
- Pascual Sánchez-Juan,
- Pau Pastor,
- Jordi Pérez-Tur,
- Gerard Piñol-Ripoll,
- Adolfo Lopez de Munain,
- Jose María García-Alberca,
- María J. Bullido,
- Victoria Álvarez,
- Alberto Lleó,
- Luis M. Real,
- Pablo Mir,
- Miguel Medina,
- Philip Scheltens,
- Henne Holstege,
- Marta Marquié,
- María Eugenia Sáez,
- Ángel Carracedo,
- Philippe Amouyel,
- Gerard D. Schellenberg,
- Julie Williams,
- Sudha Seshadri,
- Cornelia M. van Duijn,
- Karen A. Mather,
- Raquel Sánchez-Valle,
- Manuel Serrano-Ríos,
- Adelina Orellana,
- Lluís Tárraga,
- Kaj Blennow,
- Martijn Huisman,
- Ole A. Andreassen,
- Danielle Posthuma,
- Jordi Clarimón,
- Mercè Boada,
- Wiesje M. van der Flier,
- Alfredo Ramirez,
- Jean-Charles Lambert,
- Sven J. van der Lee,
- Agustín Ruiz
Affiliations
- Itziar de Rojas
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Sonia Moreno-Grau
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Niccolo Tesi
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Benjamin Grenier-Boley
- Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases
- Victor Andrade
- Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty
- Iris E. Jansen
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Nancy L. Pedersen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Najada Stringa
- Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute
- Anna Zettergren
- Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg
- Isabel Hernández
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Laura Montrreal
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Carmen Antúnez
- Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca
- Anna Antonell
- Alzheimer’s disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona
- Rick M. Tankard
- Mathematics and Statistics, Murdoch University
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Rebecca Sims
- Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
- Céline Bellenguez
- Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases
- Inés Quintela
- Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela
- Antonio González-Perez
- CAEBI, Centro Andaluz de Estudios Bioinformáticos
- Miguel Calero
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Emilio Franco-Macías
- Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla
- Juan Macías
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme
- Rafael Blesa
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Laura Cervera-Carles
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Manuel Menéndez-González
- Servicio de Neurología, Hospital Universitario Central de Asturias
- Ana Frank-García
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Jose Luís Royo
- Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga
- Fermin Moreno
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Raquel Huerto Vilas
- Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida
- Miquel Baquero
- Servei de Neurologia, Hospital Universitari i Politècnic La Fe
- Mónica Diez-Fairen
- Fundació Docència i Recerca MútuaTerrassa, Terrassa
- Carmen Lage
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Sebastián García-Madrona
- Hospital Universitario Ramon y Cajal, IRYCIS
- Pablo García-González
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Emilio Alarcón-Martín
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Sergi Valero
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Oscar Sotolongo-Grau
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Abbe Ullgren
- Karolinska Institutet, Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics
- Adam C. Naj
- Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine
- Afina W. Lemstra
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Alba Benaque
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Alba Pérez-Cordón
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Alberto Benussi
- Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia
- Alberto Rábano
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Alessandro Padovani
- Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia
- Alessio Squassina
- Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari
- Alexandre de Mendonça
- Faculty of Medicine, University of Lisbon
- Alfonso Arias Pastor
- Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida
- Almar A. L. Kok
- Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute
- Alun Meggy
- UK Dementia Research Institute at Cardiff, Cardiff University
- Ana Belén Pastor
- CIEN Foundation/Queen Sofia Foundation Alzheimer Center
- Ana Espinosa
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Anaïs Corma-Gómez
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme
- Angel Martín Montes
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Ángela Sanabria
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Anita L. DeStefano
- Department of Neurology, Boston University School of Medicine
- Anja Schneider
- Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn
- Annakaisa Haapasalo
- A.I Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Anne Kinhult Ståhlbom
- Karolinska Institutet, Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics
- Anne Tybjærg-Hansen
- Department of Clinical Biochemistry, Rigshospitalet
- Annette M. Hartmann
- Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics
- Annika Spottke
- German Center for Neurodegenerative Diseases (DZNE)
- Arturo Corbatón-Anchuelo
- Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC)
- Arvid Rongve
- Haugesund Hospital, Helse Fonna, Department of Research and Innovation
- Barbara Borroni
- Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia
- Beatrice Arosio
- Department of Clinical Sciences and Community Health, University of Milan
- Benedetta Nacmias
- Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence
- Børge G. Nordestgaard
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Brian W. Kunkle
- Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine
- Camille Charbonnier
- Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and CNR-MAJ, FHU G4 Génomique
- Carla Abdelnour
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Carlo Masullo
- Institute of Neurology, Catholic University of the Sacred Heart, School of Medicine
- Carmen Martínez Rodríguez
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
- Carmen Muñoz-Fernandez
- Servicio de Neurología, Hospital Universitario de Gran Canaria Dr.Negrín
- Carole Dufouil
- Inserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux
- Caroline Graff
- Karolinska Institutet, Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics
- Catarina B. Ferreira
- Instituto de Medicina Molecular João lobo Antunes, Faculdade de Medicina, Universidade de Lisboa
- Caterina Chillotti
- Unit of Clinical Pharmacology, University Hospital of Cagliari
- Chandra A. Reynolds
- Department of Psychology, University of California—Riverside
- Chiara Fenoglio
- University of Milan, Dino Ferrari Center
- Christine Van Broeckhoven
- VIB Center for Molecular Neurology
- Christopher Clark
- Insititute for Regenerative Medicine, University of Zürich
- Claudia Pisanu
- Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari
- Claudia L. Satizabal
- Department of Neurology, Boston University School of Medicine
- Clive Holmes
- Division of Clinical Neurosciences, School of Medicine, University of Southampton
- Dolores Buiza-Rueda
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Dag Aarsland
- Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Dan Rujescu
- Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics
- Daniel Alcolea
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Daniela Galimberti
- University of Milan, Dino Ferrari Center
- David Wallon
- Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Neurology and CNR-MAJ, FHU G4 Génomique
- Davide Seripa
- Complex Structure of Geriatrics, Department of Medical Sciences Fondazione IRCCS Casa Sollievo della Sofferenza
- Edna Grünblatt
- Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich (PUK), University of Zurich
- Efthimios Dardiotis
- School of Medicine, University of Thessaly
- Emrah Düzel
- German Center for Neurodegenerative Diseases (DZNE)
- Elio Scarpini
- University of Milan, Dino Ferrari Center
- Elisa Conti
- School of Medicine and Surgery, University of Milano-Bicocca and Milan Center for Neuroscience
- Elisa Rubino
- Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino
- Ellen Gelpi
- Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d’Investigacions Biomèdiques August Pi i Sunyer
- Eloy Rodriguez-Rodriguez
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Emmanuelle Duron
- APHP, Hôpital Brousse, equipe INSERM 1178, MOODS
- Eric Boerwinkle
- School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston
- Evelyn Ferri
- Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico
- Fabrizio Tagliavini
- Fondazione IRCCS Istituto Neurologico Carlo Besta
- Fahri Küçükali
- VIB Center for Molecular Neurology
- Florence Pasquier
- Inserm U1172, CHU, DISTAlz, LiCEND, Univ Lille
- Florentino Sanchez-Garcia
- Servicio de Inmunología, Hospital Universitario de Gran Canaria Dr. Negrín
- Francesca Mangialasche
- Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet
- Frank Jessen
- German Center for Neurodegenerative Diseases (DZNE)
- Gaël Nicolas
- Hospital de Cabueñes
- Geir Selbæk
- Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust
- Gemma Ortega
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Geneviève Chêne
- Inserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux
- Georgios Hadjigeorgiou
- Department of Neurology, Medical School, University of Cyprus
- Giacomina Rossi
- Fondazione IRCCS Istituto Neurologico Carlo Besta
- Gianfranco Spalletta
- Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation
- Giorgio Giaccone
- Fondazione IRCCS Istituto Neurologico Carlo Besta
- Giulia Grande
- Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University
- Giuliano Binetti
- MAC—Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
- Goran Papenberg
- Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University
- Harald Hampel
- Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital
- Henri Bailly
- APHP, Hôpital Broca
- Henrik Zetterberg
- Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital
- Hilkka Soininen
- Institute of Clinical Medicine Neurology, University of Eastern Finland
- Ida K. Karlsson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Ignacio Alvarez
- Fundació Docència i Recerca MútuaTerrassa, Terrassa
- Ildebrando Appollonio
- School of Medicine and Surgery, University of Milano-Bicocca and Milan Center for Neuroscience
- Ina Giegling
- Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics
- Ingmar Skoog
- Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg
- Ingvild Saltvedt
- Department of Geriatrics, Clinic of Medicine, St Olavs Hospital, University Hospital of Trondheim
- Innocenzo Rainero
- Department of Neuroscience “Rita Levi Montalcini”, University of Torino
- Irene Rosas Allende
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
- Jakub Hort
- Memory Clinic, Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Charles University
- Janine Diehl-Schmid
- Department of Psychiatry and Psychotherapy, School of Medicine Klinikum rechts der Isar, Technical University of Munich
- Jasper Van Dongen
- VIB Center for Molecular Neurology
- Jean-Sebastien Vidal
- APHP, Hôpital Broca
- Jenni Lehtisalo
- Institute of Clinical Medicine Neurology, University of Eastern Finland
- Jens Wiltfang
- Department of Psychiatry and Psychotherapy, University Medical Center Goettingen
- Jesper Qvist Thomassen
- Department of Clinical Biochemistry, Rigshospitalet
- Johannes Kornhuber
- Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg
- Jonathan L. Haines
- Department of Population & Quantitative Health Sciences, Case Western Reserve University
- Jonathan Vogelgsang
- Department of Psychiatry and Psychotherapy, University Medical Center Goettingen
- Juan A. Pineda
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme
- Juan Fortea
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Julius Popp
- Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich
- Jürgen Deckert
- Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital
- Katharina Buerger
- Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
- Kevin Morgan
- Schools of Life Sciences and Medicine, University of Nottingham
- Klaus Fließbach
- Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn
- Kristel Sleegers
- VIB Center for Molecular Neurology
- Laura Molina-Porcel
- Alzheimer’s disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona
- Lena Kilander
- Department of Public Health and Caring Sciences/Geriatrics
- Leonie Weinhold
- Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn
- Lindsay A. Farrer
- Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health
- Li-San Wang
- Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine
- Luca Kleineidam
- Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty
- Lucia Farotti
- Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia
- Lucilla Parnetti
- Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia
- Lucio Tremolizzo
- School of Medicine and Surgery, University of Milano-Bicocca and Milan Center for Neuroscience
- Lucrezia Hausner
- Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Medical Faculty Mannheim, University of Heidelberg
- Luisa Benussi
- Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
- Lutz Froelich
- Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Medical Faculty Mannheim, University of Heidelberg
- M. Arfan Ikram
- Department of Epidemiology, Erasmus Medical Center
- M. Candida Deniz-Naranjo
- Servicio de Inmunología, Hospital Universitario de Gran Canaria Dr. Negrín
- Magda Tsolaki
- 1st Department of Neurology Aristotle University of Thessaloniki
- Maitée Rosende-Roca
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Malin Löwenmark
- Department of Public Health and Caring Sciences/Geriatrics
- Marc Hulsman
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Marco Spallazzi
- Azienda Ospedaliero-Universitaria
- Margaret A. Pericak-Vance
- John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine
- Margaret Esiri
- Nuffield Department of Clinical Neurosciences
- María Bernal Sánchez-Arjona
- Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla
- Maria Carolina Dalmasso
- Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty
- María Teresa Martínez-Larrad
- Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC)
- Marina Arcaro
- Fondazione IRCCS Ca’ Granda, Ospedale Policlinico
- Markus M. Nöthen
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn
- Marta Fernández-Fuertes
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme
- Martin Dichgans
- Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
- Martin Ingelsson
- Department of Public Health and Caring Sciences/Geriatrics
- Martin J. Herrmann
- Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital
- Martin Scherer
- Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf
- Martin Vyhnalek
- Memory Clinic, Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Charles University
- Mary H. Kosmidis
- Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki
- Mary Yannakoulia
- Department of Nutrition and Dietetics, Harokopio University
- Matthias Schmid
- German Center for Neurodegenerative Diseases (DZNE)
- Michael Ewers
- Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
- Michael T. Heneka
- Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn
- Michael Wagner
- Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn
- Michela Scamosci
- Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia
- Miia Kivipelto
- Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet
- Mikko Hiltunen
- Institute of Biomedicine, University of Eastern Finland
- Miren Zulaica
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Montserrat Alegret
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Myriam Fornage
- Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston
- Natalia Roberto
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Natasja M. van Schoor
- Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute
- Nazib M. Seidu
- Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg
- Nerisa Banaj
- Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation
- Nicola J. Armstrong
- Mathematics and Statistics, Murdoch University
- Nikolaos Scarmeas
- 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School
- Norbert Scherbaum
- LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen
- Oliver Goldhardt
- Department of Psychiatry and Psychotherapy, School of Medicine Klinikum rechts der Isar, Technical University of Munich
- Oliver Hanon
- APHP, Hôpital Broca
- Oliver Peters
- Department of Psychiatry and Psychotherapy and Experimental and Clinical Research Center (ECRC), Charité-Universitätsmedizin Berlin
- Olivia Anna Skrobot
- Bristol Medical School (THS), University of Bristol, Southmead Hospital
- Olivier Quenez
- Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and CNR-MAJ, FHU G4 Génomique
- Ondrej Lerch
- Memory Clinic, Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Charles University
- Paola Bossù
- Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation
- Paolo Caffarra
- Unit of Neuroscience, DIMEC, University of Parma
- Paolo Dionigi Rossi
- Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico
- Paraskevi Sakka
- Athens Association of Alzheimer’s disease and Related Disorders
- Per Hoffmann
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn
- Peter A. Holmans
- Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
- Peter Fischer
- Department of Psychiatry, Social Medicine Center East- Donauspital
- Peter Riederer
- Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg
- Qiong Yang
- Department of Biostatistics, Boston University School of Public Health
- Rachel Marshall
- Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
- Rajesh N. Kalaria
- Translational and Clincial Research Institute, Newcastle University
- Richard Mayeux
- Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University
- Rik Vandenberghe
- Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven
- Roberta Cecchetti
- Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia
- Roberta Ghidoni
- Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
- Ruth Frikke-Schmidt
- Department of Clinical Biochemistry, Rigshospitalet
- Sandro Sorbi
- Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence
- Sara Hägg
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Sebastiaan Engelborghs
- Center for Neurosciences, Vrije Universiteit Brussel (VUB)
- Seppo Helisalmi
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
- Sigrid Botne Sando
- Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim
- Silke Kern
- Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg
- Silvana Archetti
- Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital
- Silvia Boschi
- Department of Neuroscience “Rita Levi Montalcini”, University of Torino
- Silvia Fostinelli
- Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
- Silvia Gil
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Silvia Mendoza
- Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience
- Simon Mead
- MRC Prion Unit at UCL, Institute of Prion Diseases
- Simona Ciccone
- Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico
- Srdjan Djurovic
- Department of Medical Genetics, Oslo University Hospital
- Stefanie Heilmann-Heimbach
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn
- Steffi Riedel-Heller
- Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig
- Teemu Kuulasmaa
- Institute of Biomedicine, University of Eastern Finland
- Teodoro del Ser
- Department of Neurology/CIEN Foundation/Queen Sofia Foundation Alzheimer Center
- Thibaud Lebouvier
- Inserm U1172, CHU, DISTAlz, LiCEND, Univ Lille
- Thomas Polak
- Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital
- Tiia Ngandu
- Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet
- Timo Grimmer
- Department of Psychiatry and Psychotherapy, School of Medicine Klinikum rechts der Isar, Technical University of Munich
- Valentina Bessi
- Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence
- Valentina Escott-Price
- Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
- Vilmantas Giedraitis
- Department of Public Health and Caring Sciences/Geriatrics
- Vincent Deramecourt
- Inserm U1172, CHU, DISTAlz, LiCEND, Univ Lille
- Wolfgang Maier
- Department of Neurodegenerative diseases and Geriatric Psychiatry, University Clinic Bonn
- Xueqiu Jian
- Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases
- Yolande A. L. Pijnenburg
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- EADB contributors
- The GR@ACE study group
- DEGESCO consortium
- IGAP (ADGC, CHARGE, EADI, GERAD)
- PGC-ALZ consortia
- Patrick Gavin Kehoe
- German Center for Neurodegenerative Diseases (DZNE)
- Guillermo Garcia-Ribas
- Hospital Universitario Ramon y Cajal, IRYCIS
- Pascual Sánchez-Juan
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Pau Pastor
- Fundació Docència i Recerca MútuaTerrassa, Terrassa
- Jordi Pérez-Tur
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Gerard Piñol-Ripoll
- Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida
- Adolfo Lopez de Munain
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Jose María García-Alberca
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- María J. Bullido
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Victoria Álvarez
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
- Alberto Lleó
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Luis M. Real
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme
- Pablo Mir
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Miguel Medina
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Philip Scheltens
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Henne Holstege
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Marta Marquié
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- María Eugenia Sáez
- CAEBI, Centro Andaluz de Estudios Bioinformáticos
- Ángel Carracedo
- Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela
- Philippe Amouyel
- Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases
- Gerard D. Schellenberg
- Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine
- Julie Williams
- Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University
- Sudha Seshadri
- Department of Neurology, Boston University School of Medicine
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus Medical Center
- Karen A. Mather
- Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales
- Raquel Sánchez-Valle
- Alzheimer’s disease and other cognitive disorders unit. Service of Neurology, Hospital Clínic of Barcelona. Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona
- Manuel Serrano-Ríos
- Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC)
- Adelina Orellana
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Lluís Tárraga
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Kaj Blennow
- Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital
- Martijn Huisman
- Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute
- Ole A. Andreassen
- NORMENT Centre, Institute of Clinical Medicine, University of Oslo
- Danielle Posthuma
- Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University
- Jordi Clarimón
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III
- Mercè Boada
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- Wiesje M. van der Flier
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Alfredo Ramirez
- Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty
- Jean-Charles Lambert
- Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases
- Sven J. van der Lee
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC
- Agustín Ruiz
- Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya
- DOI
- https://doi.org/10.1038/s41467-021-22491-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.
