State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;University of Chinese Academy of Sciences, Beijing 100049, China
Ji Zhejun
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
Zhang Weiqi
University of Chinese Academy of Sciences, Beijing 100049, China;Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China;CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China;China National Center for Bioinformation, Chinese Academy of Sciences, Beijing 100101, China
Qu Jing
University of Chinese Academy of Sciences, Beijing 100049, China;China National Center for Bioinformation, Chinese Academy of Sciences, Beijing 100101, China;State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing100101, China
Liu Guanghui
.State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;.University of Chinese Academy of Sciences, Beijing 100049, China;Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
As a channel for mediating exchange between the nucleus and cytoplasm, the nuclear pore complex (NPC) is a macromolecular complex composed of about 30 nucleoporins. In addition to mediating nucleocytoplasmic transport, NPC can also regulate chromatin organization and gene expression. The maintenance of stemcell homeostasis plays an essential role in the regeneration and repair of tissues, organs, and body homeostasis.More and more studies have shown that NPC and nucleoporins can regulate stem cell proliferation and differentiation, and affect stem cell homeostasis. This article reviews the related research on NPC and its influence on stemcell homeostasis, hoping to provide new ideas for the regulation and maintenance of stem cell homeostasis.
