Armaghane Danesh Bimonthly Journal (Sep 2014)
The effect of Hydro Alcoholic Extract of Quercus Species on Lipid Peroxidation and Brain Histology Following Cerebral Ischemia in Rats
Abstract
Background & aim: The production of free radicals and lipid peroxidation are harmful to health. The aim of this study was to determine the effect of the ethanol extract of Quercus species on lipid peroxidation and the histology of the gyrus dentatus after rat cerebral ischemia. Methods: In the present experimental study, thirty male Wistar rats were divided randomly into three groups. Experimental groups 1 and 2 received 500 and 1000 mg kg hydro alcoholic extract of Quercus and control group were given distilled water at the same time, respectively. In all groups, both sides of common carotid artery was blocked and then opened for 15 minutes. After fifteen days, the mice were killed and the right and left hemisphere were used to determine the level of malondialdehyde by histological studies. Data were analyzed by one-way AOVA. Results: The average number of granular cells in the dentate gyrus of experimental groups were 32.5±1.5, 31.2±2.8, respectively, which was not significantly different in comparison to the control group (p>0.05). Conclusion: Hydro alcoholic extract of Quercus species inhibit lipid peroxidation by preventing the process of reducing ischemia-reperfusion after injury of nerve cells
