Selective Release of Technetium Complexes from a Solid Phase due to C–N Bond Cleavage upon Metal Coordination

Abstract

A new method for 99mTc-labeling using solid-phase technology is described. It allows the separation of unlabeled from labeled bioactive molecules by simple filtration. The procedure is based on a site-specific C–N bond cleavage reaction initiated by the formation of [TcI(CO)3L]-complexes.

Keywords

• Cleavage reactions
• Radiopharmaceuticals
• Solid-phase synthesis
• Technetium