Comparative study of the effects of adamantane derivatives on the behavior of CD-1 mice with different phenotype of attention stability

Abstract

The effect of memantine (1 and 10 mg/kg/day), ladasten (50 mg/kg/day) and cyclantane (10 mg/kg/day) on the behavior of CD-1 mice differing in the phenotype of attention stability in the "closed enriched cross maze" test after three days of intraperitoneal administration was studied. It was found that in a subpopulation of mice with an initial attention deficit, these aminoadamantane derivatives partially restored the level of attention. The drugs equally worsened attention in a subpopulation with an initially high attention index by 40–47 % relative to the control, which indicates the absence of selectivity of the effect of these drugs with respect to attention deficit. However, this effect was not accompanied by a change in exploratory and locomotor activity, which makes it possible to make an assumption about the prospects for further study of the pharmacological effects of adamantane derivatives and optimization of their dose and duration of administration.

Keywords

• attention deficit
• memantine
• ladasten
• cyclantane
• closed enriched cross maze
• cd-1 mice