New Metabolic Influencer on Oxytocin Release: The Ghrelin
Renáta Szabó,
Rudolf Ménesi,
Andor H. Molnár,
Zita Szalai,
Lejla Daruka,
Gábor Tóth,
János Gardi,
Márta Gálfi,
Denise Börzsei,
Krisztina Kupai,
Anna Juhász,
Marianna Radács,
Ferenc A. László,
Csaba Varga,
Anikó Pósa
Affiliations
Renáta Szabó
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Rudolf Ménesi
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Andor H. Molnár
Institute of Physical Education and Sport Sciences, Gyula Juhász Faculty of Education, University of Szeged, 6725 Szeged, Hungary
Zita Szalai
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Lejla Daruka
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Gábor Tóth
Department of Medical Chemistry, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary
János Gardi
First Department of Internal Medicine, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary
Márta Gálfi
Department of Environmental Biology and Education, Gyula Juhász Faculty of Education, Institute of Applied Science, University of Szeged, 6725 Szeged, Hungary
Denise Börzsei
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Krisztina Kupai
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Anna Juhász
Department of Psychiatry, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary
Marianna Radács
Department of Environmental Biology and Education, Gyula Juhász Faculty of Education, Institute of Applied Science, University of Szeged, 6725 Szeged, Hungary
Ferenc A. László
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Csaba Varga
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Anikó Pósa
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [d-Lys3]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [d-Lys3]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.
