An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism

Yuki Makino; Takaaki Sato; Hiroki Kawamura; Shin-ichi Hachisuka; Ryo Takeno; Tadayuki Imanaka; Haruyuki Atomi

doi:10.1038/ncomms13446

Nature Communications (Nov 2016)

An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism

Yuki Makino,
Takaaki Sato,
Hiroki Kawamura,
Shin-ichi Hachisuka,
Ryo Takeno,
Tadayuki Imanaka,
Haruyuki Atomi

Affiliations

Yuki Makino: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku
Takaaki Sato: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku
Hiroki Kawamura: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku
Shin-ichi Hachisuka: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku
Ryo Takeno: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku
Tadayuki Imanaka: JST, CREST, 7, Gobancho, Chiyoda-ku
Haruyuki Atomi: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku

DOI: https://doi.org/10.1038/ncomms13446
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Archaea metabolism has unique adaptations to hostile environments. Here Makino et al. describe an unusual ADP-dependent kinase that phosphorylates free serine to O-phosphoserine and participates in an additional cysteine biosynthetic pathway in the archaeon Thermococcus kodakarensis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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