Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis
Marketa Koberska,
Ludmila Vesela,
Vladimir Vimberg,
Jakub Lenart,
Jana Vesela,
Zdenek Kamenik,
Jiri Janata,
Gabriela Balikova Novotna
Affiliations
Marketa Koberska
Institute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic
Ludmila Vesela
Institute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic
Vladimir Vimberg
Institute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic
Jakub Lenart
Institute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic
Jana Vesela
Institute of Microbiology, The Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic
Zdenek Kamenik
Institute of Microbiology, The Czech Academy of Sciences, Prague, Czech Republic
Jiri Janata
Institute of Microbiology, The Czech Academy of Sciences, Prague, Czech Republic
Resistance proteins are perceived as mechanisms protecting bacteria from the inhibitory effect of their produced antibiotics or antibiotics from competitors. Here, we report that antibiotic resistance proteins regulate lincomycin biosynthesis in response to subinhibitory concentrations of antibiotics.
