Nature Communications (Sep 2021)
Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
- Nagakumar Bharatham,
- Purnendu Bhowmik,
- Maho Aoki,
- Ui Okada,
- Sreevalli Sharma,
- Eiki Yamashita,
- Anirudh P. Shanbhag,
- Sreenath Rajagopal,
- Teby Thomas,
- Maitrayee Sarma,
- Riya Narjari,
- Savitha Nagaraj,
- Vasanthi Ramachandran,
- Nainesh Katagihallimath,
- Santanu Datta,
- Satoshi Murakami
Affiliations
- Nagakumar Bharatham
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Purnendu Bhowmik
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Maho Aoki
- Department of Life Science and Technology, Tokyo Institute of Technology
- Ui Okada
- Department of Life Science and Technology, Tokyo Institute of Technology
- Sreevalli Sharma
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Eiki Yamashita
- Institute for Protein Research, Osaka University, Suita
- Anirudh P. Shanbhag
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Sreenath Rajagopal
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Teby Thomas
- St. John’s Research Institute
- Maitrayee Sarma
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Riya Narjari
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Savitha Nagaraj
- St. John’s Medical Hospital
- Vasanthi Ramachandran
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Nainesh Katagihallimath
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Santanu Datta
- Bugworks Research India Pvt. Ltd., Centre for Cellular and Molecular Platforms, GKVK, Bellary Rd
- Satoshi Murakami
- Department of Life Science and Technology, Tokyo Institute of Technology
- DOI
- https://doi.org/10.1038/s41467-021-25679-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
OqxB is an RND (Resistance-Nodulation-Division) transporter that contributes to the antibiotic resistance in Klebsiella pneumoniae. Here, the authors report structural and functional characterization of OqxB, with insights into its substrate binding pocket and the role in fluoroquinolone resistance.
