Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group

Minh-Tram T. Nguyen; Yu-Chien Shih; Meng-Hsuan Lin; Steve R. Roffler; Chiao-Yu Hsiao; Tian-Lu Cheng; Wen-Wei Lin; En-Chi Lin; Yuh-Jyh Jong; Chin-Yuan Chang; Yu-Cheng Su

doi:10.1038/s42004-022-00709-0

Communications Chemistry (Aug 2022)

Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group

Minh-Tram T. Nguyen,
Yu-Chien Shih,
Meng-Hsuan Lin,
Steve R. Roffler,
Chiao-Yu Hsiao,
Tian-Lu Cheng,
Wen-Wei Lin,
En-Chi Lin,
Yuh-Jyh Jong,
Chin-Yuan Chang,
Yu-Cheng Su

Affiliations

Minh-Tram T. Nguyen: Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS²B), National Yang Ming Chiao Tung University
Yu-Chien Shih: Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS²B), National Yang Ming Chiao Tung University
Meng-Hsuan Lin: Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS²B), National Yang Ming Chiao Tung University
Steve R. Roffler: Institute of Biomedical Sciences, Academia Sinica
Chiao-Yu Hsiao: Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS²B), National Yang Ming Chiao Tung University
Tian-Lu Cheng: Department of Biomedical Science and Environmental Biology, Drug Development and Value Creation Research Center, Kaohsiung Medical University
Wen-Wei Lin: School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University
En-Chi Lin: Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS²B), National Yang Ming Chiao Tung University
Yuh-Jyh Jong: Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS²B), National Yang Ming Chiao Tung University
Chin-Yuan Chang: Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS²B), National Yang Ming Chiao Tung University
Yu-Cheng Su: Department of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Bio-devices (IDS²B), National Yang Ming Chiao Tung University

DOI: https://doi.org/10.1038/s42004-022-00709-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 8

Abstract

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Methoxy polyethylene glycol (mPEG) is widely attached to drug molecules to improve their therapeutic efficacy, however mPEG can induce anti-PEG antibodies that negatively impact their therapeutic effects. Here, the authors determine the co-crystal structure of the humanized 15-2b anti-mPEG antibody with mPEG, providing insights into understanding mPEG-binding specificity and antigenicity of anti-mPEG antibodies.

Published in Communications Chemistry

ISSN: 2399-3669 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.nature.com/commschem

About the journal