Nature Communications (Nov 2017)

Airway surface liquid pH is not acidic in children with cystic fibrosis

  • André Schultz,
  • Ramaa Puvvadi,
  • Sergey M. Borisov,
  • Nicole C. Shaw,
  • Ingo Klimant,
  • Luke J. Berry,
  • Samuel T. Montgomery,
  • Thien Nguyen,
  • Silvia M. Kreda,
  • Anthony Kicic,
  • Peter B. Noble,
  • Brian Button,
  • Stephen M. Stick

DOI
https://doi.org/10.1038/s41467-017-00532-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Modulation of airway surface liquid pH has been proposed as a therapy for cystic fibrosis, but whether pH is indeed altered in cystic fibrosis is controversial. Here, the authors develop a novel fibre-optic based pH measurement technology, and show that pH is not altered in children with cystic fibrosis.