Nanodrug rescues liver fibrosis via synergistic therapy with H2O2 depletion and Saikosaponin b1 sustained release

Affiliations

Mengyun Peng: School of Pharmacy, Zhejiang Chinese Medical University
Meiyu Shao: School of Pharmacy, Zhejiang Chinese Medical University
Hongyan Dong: School of Pharmacy, Zhejiang Chinese Medical University
Xin Han: School of Pharmacy, Zhejiang Chinese Medical University
Min Hao: School of Pharmacy, Zhejiang Chinese Medical University
Qiao Yang: School of Pharmacy, Zhejiang Chinese Medical University
Qiang Lyu: School of Pharmacy, Zhejiang Chinese Medical University
Dongxin Tang: Department of Science and Education, The First Affiliated Hospital of Guiyang University of Chinese Medicine
Zhe Shen: Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine
Kuilong Wang: School of Pharmacy, Zhejiang Chinese Medical University
Haodan Kuang: School of Pharmacy, Zhejiang Chinese Medical University
Gang Cao: School of Pharmacy, Zhejiang Chinese Medical University

Abstract

Enhanced anti-fibrotic effect on the liver is achieved by a multifunctional nanosystem combining CAT-like MnO2 and anti-fibrosis Saikosaponin b1