The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni

Gaurav Dugar; Sarah L. Svensson; Thorsten Bischler; Sina Wäldchen; Richard Reinhardt; Markus Sauer; Cynthia M. Sharma

doi:10.1038/ncomms11667

Nature Communications (May 2016)

The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni

Gaurav Dugar,
Sarah L. Svensson,
Thorsten Bischler,
Sina Wäldchen,
Richard Reinhardt,
Markus Sauer,
Cynthia M. Sharma

Affiliations

Gaurav Dugar: Research Centre for Infectious Diseases (ZINF), University of Würzburg
Sarah L. Svensson: Research Centre for Infectious Diseases (ZINF), University of Würzburg
Thorsten Bischler: Research Centre for Infectious Diseases (ZINF), University of Würzburg
Sina Wäldchen: Department of Biotechnology and Biophysics, University of Würzburg, Am Hubland
Richard Reinhardt: Max Planck Genome Centre Cologne, Max Planck Institute for Plant Breeding Research
Markus Sauer: Department of Biotechnology and Biophysics, University of Würzburg, Am Hubland
Cynthia M. Sharma: Research Centre for Infectious Diseases (ZINF), University of Würzburg

DOI: https://doi.org/10.1038/ncomms11667
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 18

Abstract

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The CsrA protein binds to and represses translation of certain bacterial mRNAs. Here, Dugar et al. show for the human pathogen Campylobacter jejunithat the major flagellin mRNA acts as both a target and a regulatory 'sponge' for CsrA, and is localized at the cell poles in a translation-dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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