Nature Communications (Sep 2020)
Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
- Bianca Cioni,
- Anniek Zaalberg,
- Judy R. van Beijnum,
- Monique H. M. Melis,
- Johan van Burgsteden,
- Mauro J. Muraro,
- Erik Hooijberg,
- Dennis Peters,
- Ingrid Hofland,
- Yoni Lubeck,
- Jeroen de Jong,
- Joyce Sanders,
- Judith Vivié,
- Henk G. van der Poel,
- Jan Paul de Boer,
- Arjan W. Griffioen,
- Wilbert Zwart,
- Andries M. Bergman
Affiliations
- Bianca Cioni
- Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI)
- Anniek Zaalberg
- Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI)
- Judy R. van Beijnum
- Angiogenesis laboratory, Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam
- Monique H. M. Melis
- Molecular Genetics, NKI
- Johan van Burgsteden
- Molecular Genetics, NKI
- Mauro J. Muraro
- Hubrecht Institute - KNAW and University Medical Center Utrecht
- Erik Hooijberg
- Division of Pathology, NKI
- Dennis Peters
- Core Facility Molecular Pathology, NKI
- Ingrid Hofland
- Core Facility Molecular Pathology, NKI
- Yoni Lubeck
- Division of Pathology, NKI
- Jeroen de Jong
- Division of Pathology, NKI
- Joyce Sanders
- Division of Pathology, NKI
- Judith Vivié
- Hubrecht Institute - KNAW and University Medical Center Utrecht
- Henk G. van der Poel
- Urology and Medical Oncology, NKI
- Jan Paul de Boer
- Urology and Medical Oncology, NKI
- Arjan W. Griffioen
- Angiogenesis laboratory, Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam
- Wilbert Zwart
- Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI)
- Andries M. Bergman
- Divisions of Oncogenomics, The Netherlands Cancer Institute (NKI)
- DOI
- https://doi.org/10.1038/s41467-020-18313-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Anti-androgen therapy inhibits prostate cancer (PC) progression, and is thought to act directly on cancer cells. Here the authors show that androgen receptor is expressed on normal and PC-associated macrophages, and its stimulation alters macrophage secretome to promote migration of cultured PC cell lines.
