Study of Serum Magnesium Levels and Its Relation to Glycemic Control in Patients with Type 2 Diabetes Mellitus

Abstract

Background and objectives: Diabetes mellitus is the most common endocrine disorder and the leading cause of death and disability in the world. Magnesium is the most common intracellular cation involved in insulin mediated glucose uptake. This study was conducted in type 2 diabetic patients to assess fasting blood glucose (FBS), HbA1c and serum magnesium levels and compare it with normal controls. Materials and Methods: This was a case control study which included 50 patients with type 2 diabetes mellitus and 50 healthy controls. Serum magnesium was estimated by calmagite endpoint method. HbA1c was estimated by immunoturbidimetry method. Statistical analysis was done using SPSS. Results and discussion: Decrease in mean level of serum magnesium were observed among diabetic patients. A negative correlation was observed between serum magnesium and HbA1c. A linear regression analysis showed an inverse relationship between serum magnesium and glycemic control among patients with diabetes mellitus. Conclusion: We concluded that type 2 diabetic patients who are at risk of developing microvascular complications with poor glycemic control must be regularly monitored for serum magnesium levels.

Keywords

• hba1c
• diabetes mellitus
• magnesium
• glycemic control