Research Progress on Long Noncoding RNAs and N6-Methyladenosine in Hepatocellular Carcinoma

Wenjie Zhang; Wenjie Zhang; Wenlong Wu; Qiang Meng; Long Yang; Juzheng Yuan; Zelin Tian; Rui Ding; Xuan Zhang; Jianlin Wang; Kaishan Tao

doi:10.3389/fonc.2022.907399

Frontiers in Oncology (Jul 2022)

Research Progress on Long Noncoding RNAs and N6-Methyladenosine in Hepatocellular Carcinoma

Wenjie Zhang,
Wenjie Zhang,
Wenlong Wu,
Qiang Meng,
Long Yang,
Juzheng Yuan,
Zelin Tian,
Rui Ding,
Xuan Zhang,
Jianlin Wang,
Kaishan Tao

Affiliations

Wenjie Zhang: Chinese Education Ministry’s Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, Xi’an, China
Wenjie Zhang: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Wenlong Wu: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Qiang Meng: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Long Yang: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Juzheng Yuan: Xi’an Medical University, Xi’an, China
Zelin Tian: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Rui Ding: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Xuan Zhang: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Jianlin Wang: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Kaishan Tao: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China

DOI: https://doi.org/10.3389/fonc.2022.907399
Journal volume & issue: Vol. 12

Abstract

Read online

N6-methyladenosine (m6A) is an epigenetic modification that widely exists in long noncoding RNAs (lncRNAs) and is involved in the regulation of oncogenes or tumor suppressor genes that form complex enzymes to affect the occurrence of tumors. The abnormal modification of m6A methylation can alter the overall m6A level and thus contribute to the malignant biological behaviors of hepatocellular carcinoma (HCC). LncRNAs related to m6A methylation are involved in lipogenesis, the proliferation, migration and invasion of HCC cells, the stemness of tumor cells and sorafenib resistance. In this review, we systematically elaborated the occurrence mechanism of lncRNA and m6A methylation modification in HCC and the effect of m6A methylation modification of lncRNA on the occurrence of HCC, suggesting that the combination of m6A methylation modification and lncRNA will be more meaningful as molecular markers or prognostic markers. It is helpful to provide further ideas for exploring the pathogenesis of HCC and identifying new targets for HCC treatment and diagnosis and achieve precise individual treatment of liver cancer.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords