Nature Communications (May 2018)

Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection

  • Julian A. Rycroft,
  • Bridget Gollan,
  • Grzegorz J. Grabe,
  • Alexander Hall,
  • Angela M. Cheverton,
  • Gerald Larrouy-Maumus,
  • Stephen A. Hare,
  • Sophie Helaine

DOI
https://doi.org/10.1038/s41467-018-04472-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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The recalcitrance of many infections to antibiotic treatment may be due to the presence of ‘persisters’, or non-growing, antibiotic-tolerant bacteria. Here, the authors study the structures and functions of aminoacyl-tRNA acetyltransferase toxins, and their roles in persister formation in Salmonella.