Journal of Ophthalmology (Jan 2014)

Theoretical Basis, Laboratory Evidence, and Clinical Research of Chemical Surgery of the Cornea: Cross-Linking

  • Amanda C. da Paz,
  • Patrícia A. Bersanetti,
  • Marcella Q. Salomão,
  • Renato Ambrósio,
  • Paulo Schor

DOI
https://doi.org/10.1155/2014/890823
Journal volume & issue
Vol. 2014

Abstract

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Corneal cross-linking (CXL) is increasingly performed in ophthalmology with high success rates for progressive keratoconus and other types of ectasia. Despite being an established procedure, some molecular and clinical aspects still require additional studies. This review presents a critical analysis of some established topics and others that are still controversial. In addition, this review examines new technologies and techniques (transepithelial and ultrafast CXL), uses of corneal CXL including natural products and biomolecules as CXL promoters, and evidence for in vitro and in vivo indirect effectiveness.