Антибиотики и Химиотерапия (May 2020)
THE FACTORS THAT AFFECT STAPHYLOCCUS AUREUS CELL WALL SYNTHESIS AND RESISTANCE TO ACTINOMYCIN D
Abstract
The cells of the strain S.aureus R80 strain, resistant to actinomycin D, possess a cell wall, thickened as a result of additional synthesis of peptidoglycan. Addition of D-serine or D-threonine to the environment modify the precursors of peptidoglycan and significantly decreases the strain R80 strain resistance to actinomycin D. Subingibitory concentrations of an antibiotic tunicamycin - effective inhibitor of synthesis of wall teichoic acids S.aureus - do not affect the growth of microorganism but produce a significant increase of sensitivity of the strain R80 strain to actinomycin D. The modification of the composition of peptidoglycan by D-aminoacids as well as the inhibition of the synthesis of wall teichoic acids are likely to increase permeability of a cell wall of the resistant strain S.aureus R80 strain for actinomycin D.
