Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

Mathieu F. Bakhoum; Jasmine H. Francis; Albert Agustinus; Ethan M. Earlie; Melody Di Bona; David H. Abramson; Mercedes Duran; Ignas Masilionis; Elsa Molina; Alexander N. Shoushtari; Michael H. Goldbaum; Paul S. Mischel; Samuel F. Bakhoum; Ashley M. Laughney

doi:10.1038/s41467-021-25529-z

Nature Communications (Sep 2021)

Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

Mathieu F. Bakhoum,
Jasmine H. Francis,
Albert Agustinus,
Ethan M. Earlie,
Melody Di Bona,
David H. Abramson,
Mercedes Duran,
Ignas Masilionis,
Elsa Molina,
Alexander N. Shoushtari,
Michael H. Goldbaum,
Paul S. Mischel,
Samuel F. Bakhoum,
Ashley M. Laughney

Affiliations

Mathieu F. Bakhoum: Department of Ophthalmology and Visual Science, Yale University School of Medicine
Jasmine H. Francis: Department of Surgery, Memorial Sloan Kettering Cancer Center
Albert Agustinus: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Ethan M. Earlie: Institute for Computational Biomedicine, Weill Cornell Medicine
Melody Di Bona: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
David H. Abramson: Department of Surgery, Memorial Sloan Kettering Cancer Center
Mercedes Duran: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Ignas Masilionis: The Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center, Memorial Sloan Kettering Cancer Center
Elsa Molina: Sanford Consortium for Regenerative Medicine, University of California San Diego
Alexander N. Shoushtari: Department of Medicine, Memorial Sloan Kettering Cancer Center
Michael H. Goldbaum: Department of Ophthalmology, University of California San Diego
Paul S. Mischel: Department of Pathology, Stanford University School of Medicine
Samuel F. Bakhoum: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Ashley M. Laughney: Institute for Computational Biomedicine, Weill Cornell Medicine

DOI: https://doi.org/10.1038/s41467-021-25529-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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The molecular underpinnings driving uveal melanoma (UM) progression are unknown. Here the authors show that loss of Polycomb Repressive Complex 1 triggers chromosomal instability, which promotes inflammatory signaling and migration in UM.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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