Expanding the spectrum of novel candidate genes using trio exome sequencing and identification of monogenic cause in 27.5% of 320 families with steroid-resistant nephrotic syndrome

• Ronen Schneider,
• Shirlee Shril,
• Florian Buerger,
• Konstantin Deutsch,
• Kirollos Yousef,
• Camille N. Frank,
• Ana C. Onuchic-Whitford,
• Thomas M. Kitzler,
• Youying Mao,
• Verena Klämbt,
• Muhammad Y. Zahoor,
• Katharina Lemberg,
• Amar J. Majmundar,
• Bshara Mansour,
• Ken Saida,
• Steve Seltzsam,
• Caroline M. Kolvenbach,
• Lea Maria Merz,
• Nils D. Mertens,
• Tobias Hermle,
• Nina Mann,
• Dalia Pantel,
• Abdul A. Halawi,
• Aaron Bao,
• Luca Schierbaum,
• Sophia Schneider,
• Daanya Salmanullah,
• Iddo Z. Ben-Dov,
• Itamar Sagiv,
• Loai A. Eid,
• Hazem Subhi H. Awad,
• Muna Al Saffar,
• Neveen A. Soliman,
• Marwa M. Nabhan,
• Jameela A. Kari,
• Sherif El Desoky,
• Mohamed A. Shalaby,
• Said Ooda,
• Hanan M. Fathy,
• Shrikant Mane,
• Richard P. Lifton,
• Michael J.G. Somers,
• Friedhelm Hildebrandt

Affiliations

Ronen Schneider

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Shirlee Shril

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Florian Buerger

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Konstantin Deutsch

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Kirollos Yousef

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Camille N. Frank

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Ana C. Onuchic-Whitford

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA

Thomas M. Kitzler

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Youying Mao

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Verena Klämbt

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Muhammad Y. Zahoor

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Institute of Biochemistry & Biotechnology, University of Veterinary & Animal Sciences, Lahore 54000, Pakistan

Katharina Lemberg

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Amar J. Majmundar

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Bshara Mansour

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Ken Saida

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Steve Seltzsam

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Caroline M. Kolvenbach

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Institute of Anatomy, Medical Faculty, University of Bonn, Bonn D-53113, Germany

Lea Maria Merz

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, University Hospital Leipzig, Leipzig 04103, Germany

Nils D. Mertens

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Tobias Hermle

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Nina Mann

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Dalia Pantel

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Institute of Human Genetics, Heidelberg University, Heidelberg 69117, Germany

Abdul A. Halawi

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Aaron Bao

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Luca Schierbaum

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Sophia Schneider

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Daanya Salmanullah

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

Iddo Z. Ben-Dov

Department of Nephrology and Hypertension, Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel

Itamar Sagiv

Department of Nephrology and Hypertension, Hadassah Medical Center and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel

Loai A. Eid

Pediatric Nephrology Department, Dubai Hospital, Dubai 14660, United Arab Emirates

Hazem Subhi H. Awad

Pediatric Nephrology Department, Dubai Hospital, Dubai 14660, United Arab Emirates

Muna Al Saffar

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, United Arab Emirates University, Abu Dhabi 15551, United Arab Emirates

Neveen A. Soliman

Department of Pediatrics, Center of Pediatric Nephrology & Transplantation, Kasr Al Ainy School of Medicine, Cairo University, Cairo 11562, Egypt; Egyptian Group for Orphan Renal Diseases (EGORD), Cairo 11451, Egypt

Marwa M. Nabhan

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia

Jameela A. Kari

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia

Sherif El Desoky

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia

Mohamed A. Shalaby

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Pediatric Nephrology Center of Excellence, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia

Said Ooda

Experimental and Clinical Internal Medicine Department, Medical Research Institute, Alexandria University, Alexandria 21511, Egypt

Hanan M. Fathy

Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria 21526, Egypt

Shrikant Mane

Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA

Richard P. Lifton

Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA

Michael J.G. Somers

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Corresponding author.

Friedhelm Hildebrandt

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Corresponding author. Division of Nephrology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.