The Angiotensin Converting Enzyme I/D Polymorphism in Turkish Athletes and Sedentary Controls
Günfer Turgut,
Sebahat Turgut,
Osman Genc,
Ayfer Atalay,
Erol Ömer Atalay
Affiliations
Günfer Turgut
Pamukkale University, Medical Faculty, Department of Physiology, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology (PAMGEN), Denizli, Turkey
Sebahat Turgut
Pamukkale University, Medical Faculty, Department of Physiology, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology (PAMGEN), Denizli, Turkey
Osman Genc
Pamukkale University, Medical Faculty, Department of Physiology, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology (PAMGEN), Denizli, Turkey
Ayfer Atalay
Pamukkale University, Medical Faculty, Department of Biophysics, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology (PAMGEN), Denizli, Turkey
Erol Ömer Atalay
Pamukkale University, Medical Faculty, Department of Biophysics, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology (PAMGEN), Denizli, Turkey
Summary: The angiotensin converting enzyme (ACE) gene is located on human chromosome 17 expressing three genotypes within the intron 16 of the related gene structure. These genotypes are classified as I and D alleles which are termed as insertion and deletion, respectively. This study was carried out to identify possible relationships between the insertion/ deletion (I/D) polymorphisms and athletic performance in Turkish athletes. To be able to determine these relationships, eighty healthy athletes and eighty healthy sedentary controls were genotyped for the ACE I/D polymorphism at gene level. According to the results obtained, we found significant difference on ACE I/D polymorphism in between athletes and healthy controls (x2 = 7.32, df = 2, P = 0.026). This result supports the association in ACE genotype in Turkish athletes, suggesting that this might be a genetic factor influencing the physical performance.
