White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia

Noriko Nishiyama; Hideki Kobara; Maki Ayaki; Shintaro Fujihara; Kaho Nakatani; Naoya Tada; Kazuhiro Koduka; Takanori Matsui; Tadayuki Takata; Taiga Chiyo; Nobuya Kobayashi; Tingting Shi; Koji Fujita; Joji Tani; Tatsuo Yachida; Tsutomu Masaki; Ken Haruma

doi:10.3390/jcm10122625

Journal of Clinical Medicine (Jun 2021)

White Spot, a Novel Endoscopic Finding, May Be Associated with Acid-Suppressing Agents and Hypergastrinemia

Noriko Nishiyama,
Hideki Kobara,
Maki Ayaki,
Shintaro Fujihara,
Kaho Nakatani,
Naoya Tada,
Kazuhiro Koduka,
Takanori Matsui,
Tadayuki Takata,
Taiga Chiyo,
Nobuya Kobayashi,
Tingting Shi,
Koji Fujita,
Joji Tani,
Tatsuo Yachida,
Tsutomu Masaki,
Ken Haruma

Affiliations

Noriko Nishiyama: Department of Gastroenterology, Nishiyama Neurological Hospital, Sakaide City 762-0023, Kagawa, Japan
Hideki Kobara: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Maki Ayaki: General Medical Center, Department of General Internal Medicine 2, Kawasaki Hospital, Kawasaki Medical School, Okayama City 700-8505, Okayama, Japan
Shintaro Fujihara: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Kaho Nakatani: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Naoya Tada: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Kazuhiro Koduka: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Takanori Matsui: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Tadayuki Takata: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Taiga Chiyo: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Nobuya Kobayashi: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Tingting Shi: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Koji Fujita: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Joji Tani: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Tatsuo Yachida: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Tsutomu Masaki: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, MiKi City 761-0793, Kagawa, Japan
Ken Haruma: General Medical Center, Department of General Internal Medicine 2, Kawasaki Hospital, Kawasaki Medical School, Okayama City 700-8505, Okayama, Japan

DOI: https://doi.org/10.3390/jcm10122625
Journal volume & issue: Vol. 10, no. 12
p. 2625

Abstract

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White globe appearance (WGA) is defined as a microendoscopic white lesion with a globular shape underlying the gastric epithelium and is considered a marker of gastric cancer. We recently reported that endoscopically visualized white spot (WS) corresponding to WGA appeared on the nonatrophic mucosa of patients with acid-suppressing agents (A-SA) use. We evaluated patients undergoing routine esophagogastroduodenoscopy and divided the patients into an A-SA group (n = 112) and a control group (n = 158). We compared the presence of WS in both groups. We also compared WS-positive- (n = 31) and -negative (n = 43) groups within the A-SA group regarding these patients’ backgrounds and serum gastrin concentrations. Comparing the A-SA group with controls, the prevalence of WS was significantly higher (31/112 vs. 2/158; p p p p < 0.001). WS may be associated with hypergastrinemia and potassium-competitive acid blockers.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

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