Nature Communications (May 2019)
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
- Navdeep Malik,
- Hualong Yan,
- Nellie Moshkovich,
- Murali Palangat,
- Howard Yang,
- Vanesa Sanchez,
- Zhuo Cai,
- Tyler J. Peat,
- Shunlin Jiang,
- Chengyu Liu,
- Maxwell Lee,
- Beverly A. Mock,
- Stuart H. Yuspa,
- Daniel Larson,
- Lalage M. Wakefield,
- Jing Huang
Affiliations
- Navdeep Malik
- Cancer and Stem Cell Epigenetics Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Hualong Yan
- Cancer and Stem Cell Epigenetics Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Nellie Moshkovich
- Cancer Biology of TGF-beta Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Murali Palangat
- Laboratory of Receptor Biology & Gene Expression, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Howard Yang
- High-Dimension Data Analysis Group, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Vanesa Sanchez
- In Vitro Pathogenesis Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Zhuo Cai
- Cancer and Stem Cell Epigenetics Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Tyler J. Peat
- Cancer Genetics Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Shunlin Jiang
- Cancer and Stem Cell Epigenetics Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Chengyu Liu
- Transgenic Core, National Heart, Lung, and Blood Institute, National Institutes of Health
- Maxwell Lee
- High-Dimension Data Analysis Group, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Beverly A. Mock
- Cancer Genetics Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Stuart H. Yuspa
- In Vitro Pathogenesis Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Daniel Larson
- Laboratory of Receptor Biology & Gene Expression, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Lalage M. Wakefield
- Cancer Biology of TGF-beta Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Jing Huang
- Cancer and Stem Cell Epigenetics Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-019-10102-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating translation by eIF4B.
