A digital tool for multidimensional assessment and prediction of treatment effectiveness in chronic pain management
Philippe Rigoard,
Amine Ounajim,
Maarten Moens,
Lisa Goudman,
Manuel Roulaud,
Nicolas Naiditch,
Raouf Boukenna,
Philippe Page,
Bénédicte Bouche,
Bertille Lorgeoux,
Sandrine Baron,
Kevin Nivole,
Mathilde Many,
Lucie Lampert,
Géraldine Brumauld de Montgazon,
Brigitte Roy-Moreau,
Romain David,
Maxime Billot
Affiliations
Philippe Rigoard
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France; CHU de Poitiers, service de neurochirurgie du rachis, chirurgie de la douleur et du handicap, 86000 Poitiers, France; Université de Poitiers, Pprime Institute UPR 3346, CNRS, ISAE-ENSMA, 86000 Poitiers, France
Amine Ounajim
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Maarten Moens
Department of Neurosurgery, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium; STIMULUS consortium (reSearch and TeachIng neuroModULation Uz bruSsel), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Department of Radiology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
Lisa Goudman
Department of Neurosurgery, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium; STIMULUS consortium (reSearch and TeachIng neuroModULation Uz bruSsel), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Research Foundation—Flanders (FWO), 1090 Brussels, Belgium
Manuel Roulaud
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Nicolas Naiditch
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Raouf Boukenna
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Philippe Page
CHU de Poitiers, service de neurochirurgie du rachis, chirurgie de la douleur et du handicap, 86000 Poitiers, France
Bénédicte Bouche
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France; CHU de Poitiers, service de neurochirurgie du rachis, chirurgie de la douleur et du handicap, 86000 Poitiers, France
Bertille Lorgeoux
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Sandrine Baron
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Kevin Nivole
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Mathilde Many
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Lucie Lampert
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France
Géraldine Brumauld de Montgazon
Pain Evaluation and Treatment Centre, La Rochelle Hospital, 17000 La Rochelle, France
Brigitte Roy-Moreau
Pain Evaluation and Treatment Centre, Nord Deux-Sèvres Hospital, 79350 Faye-l'Abbesse, France
Romain David
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France; CHU de Poitiers, service de médecine physique et réadaptation, 86000 Poitiers, France
Maxime Billot
CHU de Poitiers, PRISMATICS Lab (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), 86000 Poitiers, France; Centre de Recherche sur la Cognition et l’Apprentissage, Université de Poitiers, Université François Rabelais de Tours, CNRS, 86000 Poitiers, France; Corresponding author
Summary: Given the multidimensional aspect of pain, the assessment of treatment efficacy is challenging. The prospective observational multicenter PREDIBACK study aimed to assess, compare, and predict the effectiveness of different treatments for persistent spinal pain syndrome type 2 (PSPS-T2) using a digital tool and the Multidimensional Clinical Response Index (MCRI) including pain intensity, functional disability, quality of life, anxiety and depression, and pain surface. Results indicated that neurostimulation was the most effective treatment at 3-, 6-, 9-, and 12-month follow-up compared to baseline, leading to significant improvements in pain, function, and quality of life, whereas optimized medical management (OMM) and spinal reoperation showed no significant benefits. Additionally, the study identified pain surface, BMI, and smoking status as predictors of treatment outcomes. These findings highlight the potential of digital medicine to improve patient care by providing data-driven insights and personalized treatment recommendations for PSPS-T2.
