Direct observation of chaperone-modulated talin mechanics with single-molecule resolution

Soham Chakraborty; Deep Chaudhuri; Souradeep Banerjee; Madhu Bhatt; Shubhasis Haldar

doi:10.1038/s42003-022-03258-3

Communications Biology (Apr 2022)

Direct observation of chaperone-modulated talin mechanics with single-molecule resolution

Soham Chakraborty,
Deep Chaudhuri,
Souradeep Banerjee,
Madhu Bhatt,
Shubhasis Haldar

Affiliations

Soham Chakraborty: Department of Biological Sciences, Ashoka University
Deep Chaudhuri: Department of Biological Sciences, Ashoka University
Souradeep Banerjee: Department of Biological Sciences, Ashoka University
Madhu Bhatt: Department of Biological Sciences, Ashoka University
Shubhasis Haldar: Department of Biological Sciences, Ashoka University

DOI: https://doi.org/10.1038/s42003-022-03258-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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Chakraborty et al. uses single-molecule magnetic tweezers to investigate the chaperone-modulated talin protein mechanics. The results showed that chaperones are involved in the regulation of talin folding/unfolding under mechanical force with some chaperones stabilizing talin and increasing the force, whereas others destabilize it and reduce the force.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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