A photoacoustic finder fully integrated with a solid-state dye laser and transparent ultrasound transducer

Byullee Park; Moongyu Han; Jeongwoo Park; Taejeong Kim; Hanyoung Ryu; Youngseok Seo; Won Jong Kim; Hyung Ham Kim; Chulhong Kim

Photoacoustics (Sep 2021)

A photoacoustic finder fully integrated with a solid-state dye laser and transparent ultrasound transducer

Byullee Park,
Moongyu Han,
Jeongwoo Park,
Taejeong Kim,
Hanyoung Ryu,
Youngseok Seo,
Won Jong Kim,
Hyung Ham Kim,
Chulhong Kim

Affiliations

Byullee Park: Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, and School of Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, 37673, Republic of Korea
Moongyu Han: Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, and School of Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, 37673, Republic of Korea
Jeongwoo Park: Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, and School of Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, 37673, Republic of Korea
Taejeong Kim: Department of Chemistry, Postech-Catholic Biomedical Engineering Institute, School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-ro, Nam-gu, Pohang, 37673, Republic of Korea
Hanyoung Ryu: R&D center, Wontech Co. Ltd., Daejeon, 34028, Republic of Korea
Youngseok Seo: R&D center, Wontech Co. Ltd., Daejeon, 34028, Republic of Korea
Won Jong Kim: Department of Chemistry, Postech-Catholic Biomedical Engineering Institute, School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-ro, Nam-gu, Pohang, 37673, Republic of Korea
Hyung Ham Kim: Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, and School of Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, 37673, Republic of Korea; Corresponding authors.
Chulhong Kim: Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, and School of Interdisciplinary Bioscience and Bioengineering, Medical Device Innovation Center, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, 37673, Republic of Korea; Corresponding authors.

Journal volume & issue: Vol. 23
p. 100290

Abstract

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The standard-of-care for evaluating lymph node status in breast cancers and melanoma metastasis is sentinel lymph node (SLN) assessment performed with a handheld gamma probe and radioisotopes. However, this method inevitably exposes patients and physicians to radiation, and the special facilities required limit its accessibility. Here, we demonstrate a non-ionizing, cost-effective, handheld photoacoustic finder (PAF) fully integrated with a solid-state dye laser and transparent ultrasound transducer (TUT). The solid-state dye laser handpiece is coaxially aligned with the spherically focused TUT. The integrated finder readily detected photoacoustic signals from a tube filled with methylene blue (MB) beneath a 22 mm thick layer of chicken tissue. In live animals, we also photoacoustically detected both SLNs injected with MB and subcutaneously injected melanomas. We believe that our radiation-free and inexpensive PAF can play a vital role in SLN assessment.

Published in Photoacoustics

ISSN: 2213-5979 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Physics: Acoustics. Sound; Science: Physics: Optics. Light
Website: http://www.journals.elsevier.com/photoacoustics/

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