Alpha-amylase Inhibitory Activity of Sitopaladi Churna: An Ayurvedic Formula

Abstract

Sitopaladi Churna is an ayurvedic formula, traditionally used as anti-inflammatory, carminative, sedative, expectorant, anti-infective, and various respiratory disorders. The aim of the present study is to screening for alpha amylase (α-amylase) inhibition activity of aqueous extract of Sitopaladi Churna. In vitro α-amylase inhibition activity of Sitopaladi Churna was screened by the 3,5-dinitrosalicylic acid method. Sitopaladi Churna showed potent (α-amylase) inhibitory activity with an IC50 - 46.38 µ g/ml. Thus, Sitopaladi Churna may consider as a remedy for diabetes and other insulin resistance-related diseases; however, animal and human studies are needed to confirm this activity.

Keywords

• Sitopaladi churna
• Ayurvedic formula
• Diabetes
• Alpha amylase
• Dinitrosalicylic acid