APPLICATION OF PERFTORAN AND RECOMBINANT SUPEROXIDE DISMUTASE IN COMPLEX TREATMENT OF ENTERAL INSUFFICIENCY IN PATIENTS WITH ACUTE INTESTINAL OBSTRUCTION

Abstract

The effectiveness of perftoran and recombinant superoxide dismutase in complex post-operative therapy in patients with acute intestinal obstruction was investigated. All patients (two groups) were combined. 49 patients received traditional complex therapy, 42 patients during the operation were given additional intravenous infusion recombinant superoxide dismutase and perftoran. Leucocyte intoxication index, the concentration of middle-weight molecules, dien conjugats and malone dialdehyde in serum, iron-induced and spontaneous chemiluminescence of blood serum, superoxide dismutase activity and catalase of erythrocyte at all patients were determined. It was established application of the perftoran and recombinant superoxide dismutase promotes the decrease of free-radical processes intensity, the reduction of endogenous intoxication and reduces the risk of the evident intestinal insufficiency development in patients with acute intestinal obstruction.

Keywords

• острая кишечная непроходимость
• энтеральная недостаточность
• перфторан
• супероксиддисмутаза