(<i>E</i>)-4-Oxo-3,4-dihydroquinazoline-2-carbaldehyde Oxime

Abstract

Reaction of 4-oxo-3,4-dihydroquinazoline-2-carbaldehyde with hydroxylamine hydrochloride (1.1 equiv) in the presence of K2CO3 (1 equiv) gave (E)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde oxime (8) in 58% yield. The compound was fully characterized and the conformation of the oxime was supported by single crystal x-ray diffractometry.

Keywords

• heterocycle
• polyfunctionalized
• quinazoline
• oxime