Nature Communications (Jan 2021)
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
- Simon Renders,
- Arthur Flohr Svendsen,
- Jasper Panten,
- Nicolas Rama,
- Maria Maryanovich,
- Pia Sommerkamp,
- Luisa Ladel,
- Anna Rita Redavid,
- Benjamin Gibert,
- Seka Lazare,
- Benjamin Ducarouge,
- Katharina Schönberger,
- Andreas Narr,
- Manon Tourbez,
- Bertien Dethmers-Ausema,
- Erik Zwart,
- Agnes Hotz-Wagenblatt,
- Dachuan Zhang,
- Claudia Korn,
- Petra Zeisberger,
- Adriana Przybylla,
- Markus Sohn,
- Simon Mendez-Ferrer,
- Mathias Heikenwälder,
- Maik Brune,
- Daniel Klimmeck,
- Leonid Bystrykh,
- Paul S. Frenette,
- Patrick Mehlen,
- Gerald de Haan,
- Nina Cabezas-Wallscheid,
- Andreas Trumpp
Affiliations
- Simon Renders
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Arthur Flohr Svendsen
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Jasper Panten
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Nicolas Rama
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée “La Ligue,” LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard
- Maria Maryanovich
- Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
- Pia Sommerkamp
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Luisa Ladel
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Anna Rita Redavid
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée “La Ligue,” LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard
- Benjamin Gibert
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée “La Ligue,” LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard
- Seka Lazare
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Benjamin Ducarouge
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée “La Ligue,” LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard
- Katharina Schönberger
- Max Planck Institute of Immunobiology and Epigenetics
- Andreas Narr
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Manon Tourbez
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Bertien Dethmers-Ausema
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Erik Zwart
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Agnes Hotz-Wagenblatt
- Core Facility Omics IT and Data Management, German Cancer Research Center (DKFZ)
- Dachuan Zhang
- Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
- Claudia Korn
- Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Cambridge
- Petra Zeisberger
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Adriana Przybylla
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Markus Sohn
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Simon Mendez-Ferrer
- Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Cambridge
- Mathias Heikenwälder
- Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ)
- Maik Brune
- Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital
- Daniel Klimmeck
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- Leonid Bystrykh
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Paul S. Frenette
- Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine
- Patrick Mehlen
- Apoptosis, Cancer and Development Laboratory, Equipe labellisée “La Ligue,” LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard
- Gerald de Haan
- Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Nina Cabezas-Wallscheid
- Max Planck Institute of Immunobiology and Epigenetics
- Andreas Trumpp
- Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance
- DOI
- https://doi.org/10.1038/s41467-020-20801-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 production during ageing leads to decreased Neo1 mediated HSC self-renewal.
