Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

Ming Chen; Lixin Wan; Jiangwen Zhang; Jinfang Zhang; Lourdes Mendez; John G. Clohessy; Kelsey Berry; Joshua Victor; Qing Yin; Yuan Zhu; Wenyi Wei; Pier Paolo Pandolfi

doi:10.1038/s41467-017-02272-y

Nature Communications (Jan 2018)

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

Ming Chen,
Lixin Wan,
Jiangwen Zhang,
Jinfang Zhang,
Lourdes Mendez,
John G. Clohessy,
Kelsey Berry,
Joshua Victor,
Qing Yin,
Yuan Zhu,
Wenyi Wei,
Pier Paolo Pandolfi

Affiliations

Ming Chen: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Lixin Wan: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Jiangwen Zhang: School of Biological Sciences, The University of Hong Kong
Jinfang Zhang: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Lourdes Mendez: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
John G. Clohessy: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Kelsey Berry: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Joshua Victor: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Qing Yin: Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute
Yuan Zhu: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Wenyi Wei: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Pier Paolo Pandolfi: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-017-02272-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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