Hematology, Transfusion and Cell Therapy (Dec 2024)

Clinical and prognostic significance of CD27 and CD44 expression patterns in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia

  • Asmaa Abobakr,
  • Randa A. Osman,
  • Mohamed A.M. Kamal,
  • Sayed Abdelhameed,
  • Hagar Ismail,
  • Mahmoud M. Kamel,
  • Khalaf F. Alsharif,
  • Nema R. Hamad

Journal volume & issue
Vol. 46
pp. S27 – S35

Abstract

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Introduction: The expression pattern of CD27 and CD44 was found to correlate with the differentiation stages of B cell precursors, which were known to be involved in a variety of immunological responses. Aim of the study: This study aimed to determine the biological significance of CD27 and CD44 expression in patients with B-precursor acute lymphoblastic leukemia (B-ALL), as well as their association with standard prognostic factors and therapeutic response. Patients and methods: This case-control study included 60 pediatric patients newly diagnosed with B-ALL and 30 pediatric controls. The patient CD27 and CD44 levels were measured using the Beckman Coulter Navios Flow Cytometer. Results: Most malignant cells (91.6 %) expressed CD44, but only 50 % of the patients had CD27 expressed. The positive CD 44 expression was associated with unfavorable prognostic markers, including a decrease

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