Nature Communications (Nov 2019)

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation

  • Julia Schewe,
  • Eric Seidel,
  • Sofia Forslund,
  • Lajos Marko,
  • Jörg Peters,
  • Dominik N. Muller,
  • Christoph Fahlke,
  • Gabriel Stölting,
  • Ute Scholl

DOI
https://doi.org/10.1038/s41467-019-13033-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Mutations in the chloride channel ClC-2 have been associated with familial forms of hyperaldosteronism. Here, Schewe et al. generated a mouse model carrying the most common mutation found in patients and find it recapitulates key features of the disease, providing a unique tool for future studies on its pathogenesis.