Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort

Dominik Menges; Kyra D. Zens; Tala Ballouz; Nicole Caduff; Daniel Llanas-Cornejo; Hélène E. Aschmann; Anja Domenghino; Céline Pellaton; Matthieu Perreau; Craig Fenwick; Giuseppe Pantaleo; Christian R. Kahlert; Christian Münz; Milo A. Puhan; Jan S. Fehr

doi:10.1038/s41467-022-32573-w

Nature Communications (Aug 2022)

Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort

Dominik Menges,
Kyra D. Zens,
Tala Ballouz,
Nicole Caduff,
Daniel Llanas-Cornejo,
Hélène E. Aschmann,
Anja Domenghino,
Céline Pellaton,
Matthieu Perreau,
Craig Fenwick,
Giuseppe Pantaleo,
Christian R. Kahlert,
Christian Münz,
Milo A. Puhan,
Jan S. Fehr

Affiliations

Dominik Menges: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)
Kyra D. Zens: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)
Tala Ballouz: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)
Nicole Caduff: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)
Daniel Llanas-Cornejo: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)
Hélène E. Aschmann: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)
Anja Domenghino: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)
Céline Pellaton: Service of Immunology and Allergy, Lausanne University Hospital (CHUV), University of Lausanne (UNIL)
Matthieu Perreau: Service of Immunology and Allergy, Lausanne University Hospital (CHUV), University of Lausanne (UNIL)
Craig Fenwick: Service of Immunology and Allergy, Lausanne University Hospital (CHUV), University of Lausanne (UNIL)
Giuseppe Pantaleo: Service of Immunology and Allergy, Lausanne University Hospital (CHUV), University of Lausanne (UNIL)
Christian R. Kahlert: Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen
Christian Münz: Institute for Experimental Immunology, University of Zurich (UZH)
Milo A. Puhan: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)
Jan S. Fehr: Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH)

DOI: https://doi.org/10.1038/s41467-022-32573-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The persistence of the immune response to SARS-CoV-2 after recovery from infection is an indicator for subsequent protection against infection. Here the authors follow recovered patients and measure antibody and T cell responses and find that these two parts of the immune response may have different longevity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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