Vaccines (Nov 2023)
Risk Awareness as a Key Determinant of Early Vaccine Uptake in the Mpox Vaccination Campaign in an Italian Region: A Cross-Sectional Analysis
- Giulia Del Duca,
- Alessandro Tavelli,
- Ilaria Mastrorosa,
- Camilla Aguglia,
- Simone Lanini,
- Anna Clelia Brita,
- Roberta Gagliardini,
- Serena Vita,
- Alessandra Vergori,
- Jessica Paulicelli,
- Giorgia Natalini,
- Angela D’Urso,
- Pierluca Piselli,
- Paola Gallì,
- Vanessa Mondillo,
- Claudio Mastroianni,
- Enrica Tamburrini,
- Loredana Sarmati,
- Christof Stingone,
- Miriam Lichtner,
- Emanuele Nicastri,
- Massimo Farinella,
- Filippo Leserri,
- Andrea Siddu,
- Fabrizio Maggi,
- Antonella d’Arminio Monforte,
- Francesco Vairo,
- Alessandra Barca,
- Francesco Vaia,
- Enrico Girardi,
- Valentina Mazzotta,
- Andrea Antinori
Affiliations
- Giulia Del Duca
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Alessandro Tavelli
- Icona Foundation, 20142 Milan, Italy
- Ilaria Mastrorosa
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Camilla Aguglia
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Simone Lanini
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Anna Clelia Brita
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Roberta Gagliardini
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Serena Vita
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Alessandra Vergori
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Jessica Paulicelli
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Giorgia Natalini
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Angela D’Urso
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Pierluca Piselli
- Department of Epidemiology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Paola Gallì
- Health Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Vanessa Mondillo
- Health Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Claudio Mastroianni
- Department of Public Health and Infectious Diseases, Sapienza University, AOU Policlinico Umberto 1, 00161 Rome, Italy
- Enrica Tamburrini
- Fondazione Policlinico A. Gemelli, Catholic University of the Sacred Heart, 00168 Rome, Italy
- Loredana Sarmati
- Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
- Christof Stingone
- STI/HIV Unit, San Gallicano IRCCS Dermatological Institute, 00144 Rome, Italy
- Miriam Lichtner
- Neuroscience Mental Health and Sense Organs Department, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy
- Emanuele Nicastri
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Massimo Farinella
- Circolo di Cultura Omosessuale Mario Mieli, 00146 Rome, Italy
- Filippo Leserri
- Plus Roma, 00182 Rome, Italy
- Andrea Siddu
- General Directorate of Prevention, Ministry of Health, 00197 Rome, Italy
- Fabrizio Maggi
- Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Antonella d’Arminio Monforte
- Icona Foundation, 20142 Milan, Italy
- Francesco Vairo
- Department of Epidemiology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Alessandra Barca
- Unit of Health Promotion and Prevention, Directorate of Health and Integration, Lazio Region, 00145 Rome, Italy
- Francesco Vaia
- General Directorate of Prevention, Ministry of Health, 00197 Rome, Italy
- Enrico Girardi
- Scientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Valentina Mazzotta
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- Andrea Antinori
- Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy
- DOI
- https://doi.org/10.3390/vaccines11121761
- Journal volume & issue
-
Vol. 11,
no. 12
p. 1761
Abstract
Background: we aim to investigate attitudes toward vaccination by analyzing empirical factors associated with vaccine acceptance in the Lazio region mpox vaccination (MpoxVax) campaign in Italy. Methods: all subjects who accessed MpoxVax and signed the informed consent were prospectively enrolled in the MPOX-VAC Study and were asked to fill out an anonymous survey. Two endpoints were selected: ‘delayed acceptance’ and ‘early acceptance’, defined as access for vaccination >60 and ≤30 days from the vaccination campaign starting (VCS), respectively. Results: over the study period, 1717 individuals underwent vaccination: 129 (7%) > 60 [1588 (92.5%) ≤ 60] and 676 (60%) ≤ 30 days from VCS. A bisexual orientation, a lower education level and a worse perceived physical and mental health were associated with delayed access to vaccination. Being pre-exposure prophylaxis (PrEP) users and, marginally, HIV positive; having a high perceived risk for mpox infection; and reporting high-risk behaviors like the use of recreational drugs/chems, sex under the influence of drugs and/or alcohol and having a higher number of principal sexual partners, were associated with early access to vaccination. Conclusions: according to our data, risk awareness was a major determinant of early MpoxVax acceptance. Conversely, worse perceived health status and a low educational level were critical factors associated with delayed vaccination.
Keywords
- mpox infection
- mpox vaccination
- risk awareness
- vaccine acceptance
- vaccine hesitancy
- health-related quality of life