Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection

Judy Chen; Jane C. Deng; Rachel L. Zemans; Karim Bahmed; Beata Kosmider; Min Zhang; Marc Peters-Golden; Daniel R. Goldstein

doi:10.1038/s41467-022-34593-y

Nature Communications (Nov 2022)

Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection

Judy Chen,
Jane C. Deng,
Rachel L. Zemans,
Karim Bahmed,
Beata Kosmider,
Min Zhang,
Marc Peters-Golden,
Daniel R. Goldstein

Affiliations

Judy Chen: Department of Internal Medicine, University of Michigan
Jane C. Deng: Department of Internal Medicine, University of Michigan
Rachel L. Zemans: Department of Internal Medicine, University of Michigan
Karim Bahmed: Center for Inflammation and Lung Research, Department of Microbiology, Immunology, and Inflammation, Temple University
Beata Kosmider: Center for Inflammation and Lung Research, Department of Microbiology, Immunology, and Inflammation, Temple University
Min Zhang: Department of Biostatistics, University of Michigan
Marc Peters-Golden: Department of Internal Medicine, University of Michigan
Daniel R. Goldstein: Department of Internal Medicine, University of Michigan

DOI: https://doi.org/10.1038/s41467-022-34593-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Ageing has been associated with impaired function of alveolar macrophages and increased susceptibility, mortality and complications as a result of viral infection. Here, the authors show that prostaglandin E2 is one of the factors responsible for impairing immune defences against influenza during ageing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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