Outcome of lung transplantation in cystic fibrosis patients with severe asymmetric chest cavitiesCentral MessagePerspective
Katharina Sinn, MD,
Theresa Stork, MD,
Stefan Schwarz, MD,
Tomaz Stupnik, MD,
Martin Kurz, MD,
Peter Jaksch, MD, PhD,
Walter Klepetko, MD,
Konrad Hoetzenecker, MD, PhD,
Gyoergy Lang, MD, PhD,
Jose Matilla, MD,
Bernhard Moser, MD, PhD,
Mir Alireza Hoda, MD, PhD,
Shahrokh Taghavi, MD,
Edda Tschernko, MD
Affiliations
Katharina Sinn, MD
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
Theresa Stork, MD
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
Stefan Schwarz, MD
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
Tomaz Stupnik, MD
Department of Thoracic Surgery, Ljubljana University Medical Centre, Ljubljana, Slovenia
Martin Kurz, MD
Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria
Peter Jaksch, MD, PhD
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
Walter Klepetko, MD
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
Konrad Hoetzenecker, MD, PhD
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria; Address for reprints: Konrad Hoetzenecker, MD, PhD, Department of Thoracic Surgery, Medical University of Vienna, Waehringer Gürtel 18-20, A-1090 Vienna, Austria.
Objective: A small but relevant proportion of patients with cystic fibrosis develop severely asymmetric chest cavities during the course of their disease. For these patients, the best surgical approach for lung transplantation (LTx) and optimal size matching strategies are controversial. Methods: All cystic fibrosis patients with asymmetric chest cavities who underwent LTx at the Medical University of Vienna between 2003 and 2017 were identified (n = 13). Patients were grouped according to different surgical strategies: unilateral full-size and contralateral lobar transplantation (n = 4), standard double LTx after mobilization/repositioning of the mediastinum (n = 3), oversized single LTx followed by pneumonectomy on the smaller contralateral side (n = 4), and single LTx after a remote contralateral pneumonectomy (n = 2). Results: Compared with cystic fibrosis patients with symmetric chests (n = 276, control group), the perioperative management of patients with asymmetric chests was often more complicated. Consequently, 90-day mortality was heightened (23.1% vs 6.5%). Despite this, long-term survival was good with a 5-year survival rate of 69% compared with 78%. Of note, outcome seemed superior for patients who surgery was undertaken with a bilateral compared with a unilateral approach. Conclusions: Severely asymmetric chest cavities present challenges in regard to the surgical strategy, size matching, and postoperative management. However, in carefully selected patients, LTx provides an adequate long-term outcome.
