Prognostic value analysis and survival model construction of different treatment methods for advanced intestinal type gastric adenocarcinoma
Shuangai Liu,
Yizhou Zhuang,
Qibo Fu,
Zhongyuan Zhang,
Kai Hang,
Ting Tao,
Lei Liu,
Jiheng Wu,
Yuanmei Liu,
Jinhu Wang
Affiliations
Shuangai Liu
Department of Pediatric Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Guizhou Children's Hospital, Zunyi, China; Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China
Yizhou Zhuang
Fujian Provincial Key Laboratory of Geriatric Diseases, Fujian Medical University, Fujian Provincial Hospital, Fujian Provincial Institute of Clinical Geriatrics, Fuzhou, China
Qibo Fu
National Clinical Trial Institute, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Zhongyuan Zhang
Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China
Kai Hang
Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China
Ting Tao
Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China
Lei Liu
Department of Pathology, Children's Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China
Jiheng Wu
Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China; National Clinical Trial Institute, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China; Corresponding author. Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China.
Yuanmei Liu
Department of Pediatric Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Guizhou Children's Hospital, Zunyi, China; Department of Pediatric Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Corresponding author. Department of Pediatric Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Jinhu Wang
Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China; Department of Surgical Oncology, Children's Hospital Zhejiang University School of Medicine, Hangzhou, China; Corresponding author. Department of Surgical Oncology, Children's Hospital Zhejiang University School of Medicine, Hangzhou, China.
Background: Intestinal-type gastric adenocarcinoma, representing 95 % of gastric malignancies, originates from the malignant transformation of gastric gland cells. Despite its prevalence, existing methods for prognosis evaluation of this cancer subtype are inadequate. This study aims to enhance patient-specific prognosis evaluation by analyzing the clinicopathological characteristics and prognostic risk factors of intestinal-type gastric adenocarcinoma patients using data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (NCI). Methods: We extracted clinical data for patients diagnosed with intestinal-type gastric adenocarcinoma between 2010 and 2015 from the SEER database, selecting 257 cases based on predefined inclusion and exclusion criteria. Independent risk factors for overall survival (OS) and cancer-specific survival (CSS) were identified using a Cox regression model. A nomogram model for predicting OS or CSS was developed from the Cox risk regression analysis and validated through the consistency index (C-index), ROC curve, and calibration curve. Results: Age, primary tumor resection, chemotherapy, lymph node metastasis, and tumor size were identified as independent prognostic factors for OS and CSS (P < 0.05). The nomogram model, constructed from these indicators, demonstrated superior predictive consistency for OS and CSS compared to the AJCC-TNM staging system. ROC curve analysis confirmed the model's higher accuracy, and calibration curve analysis indicated good agreement between the nomogram's predictions and actual observed outcomes. Conclusion: The nomogram model derived from SEER database analyses accurately predicts OS and CSS for patients with intestinal-type gastric adenocarcinoma. This model promises to facilitate more tailored treatments in clinical practice.
