Ultrasound-Accelerated Amide Coupling Reactions Directed toward the Synthesis of 1-Acetyl-3-carboxamide-β-carboline Derivatives of Biological Importance
N. Sharma,
P. Kumari,
P. Sharma,
N. Bhagat,
S. Bhagat
Affiliations
N. Sharma
Organic Synthesis research Laboratory, Department of Chemistry, A.R.S.D. College, University of Delhi
P. Kumari
Organic Synthesis research Laboratory, Department of Chemistry, A.R.S.D. College, University of Delhi
P. Sharma
Organic Synthesis research Laboratory, Department of Chemistry, A.R.S.D. College, University of Delhi
N. Bhagat
Instrumentation & Control Engineering, Netaji Subash Institute of Technology, University of Delhi
S. Bhagat
Organic Synthesis research Laboratory, Department of Chemistry, A.R.S.D. College, University of Delhi
Abstract Several biologically important 1-acetyl-3-carboxamide-β-carboline derivatives were rapidly synthesized by ultrasound-promoted amide coupling of 1-acetyl-9H-pyrido[3,4-b]indole-3-carboxylic acid with substituted aromatic amines. The major advantages of the proposed method are that use of ultrasound irradiations afforded the desired products in a drastically reduced reaction time and in excellent yields compared with conventional stirring.
