Chinese Journal of Contemporary Neurology and Neurosurgery (Apr 2024)

The primary exploration in clinical value of the CLSA ⁃ EA questionnaire (Chinese version) in adult epilepsy screening

  • SHI Fan-fan,
  • LI Hua,
  • CHEN Qian,
  • HUANG Li-tao,
  • YANG Rui-qi,
  • CHEN Lei

DOI
https://doi.org/10.3969/j.issn.1672-6731.2024.04.011
Journal volume & issue
Vol. 24, no. 4
pp. 265 – 272

Abstract

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Objective To evaluate the reliability, validity and diagnostic accuracy of the Canadian Longitudinal Study on Aging Epilepsy Algorithm (CLSA-EA) questionnaire (Chinese version) in screening Chinese adult epilepsy. Methods From August to October 2022, a total of 384 subjects and patients were included, who were respectively screened from urban and rural communities in Chengdu, Sichuan, and Department of Neurology of West China Hospital, Sichuan University. The CLSA - EA questionnaire (Chinese version) was used for the survey. Epilepsy was diagnosed according to 2014 International League Against Epilepsy (ILAE) criteria. Kappa coefficient and Cronbach's α coefficient were used to evaluate testretest reliability and internal consistency, respectively. Construct validity was used to test validity. The accuracy, sensitivity, specificity, positive predictive value, negative predictive value and diagnostic consistency κ value were calculated by confusion matrix method to evaluate the effect of screening. Results Finally, 348 questionnaires were obtained, including 190 epileptic cases (54.60%) and 158 nonepileptic cases (45.40%), of which 244 were retested subjects, including 123 epileptic cases (50.41%) and 121 non-epileptic cases (49.59%). Retest reliability analysis in epileptic cases showed that the consistency of items Q3a, Q3bⅲ , Q3bⅳ , Q4a and Q4b in CLSA-EA questionnaire (Chinese version) had moderate consistency (0.400 ≤ κ 0.05, for all). The internal consistency evaluation in epileptic cases showed that the internal consistency of all items and the sum of all items in the CLSA-EA questionnaire (Chinese version) were poor (Cronbach's α coefficient 0.900, for all). Conclusions The CLSA - EA questionnaire (Chinese version) has high sensitivity and specificity, which can guide the preliminary screening of epilepsy in China. However, the applicability, reliability and validity still need to be further considered.

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