Efficacy of anterior inferior cerebellar artery infusion of urokinase in sudden vascular deafness

Abstract

Objective To observe the efficacy of superselective trans⁃microcatheter intra⁃anterior inferior cerebellar artery thrombolytic therapy with urokinase for patients with sudden vascular deafness. Methods Seventy ⁃ four cases of sudden vascular deafness were randomly treated by transarterial or transvenous urokinase thrombolytic therapy. After thrombolysis, low molecular weight heparin subcutaneous injection of 0.40 ml (2 times/d) and aspirin 100 mg oral (1 time/d) were given continuously for 7 days. Electric audiometry was performed at day 1, 3, 6, 10 to assess the efficacy. Results At day 10, the total effective rate of patients given with transarterial thrombolysis (intra⁃arterial group) was 84.21% (32/38), and the patients given with transvenous thrombolysis (intra⁃venous group) was 58.33% (21/36), the difference between two groups was significant (χ2 = 6.091, P = 0.014). The results of electric audiometry at different time points in intra⁃arterial group were all better than those in intra⁃venous group, the differences were all significant (P < 0.01, for all). Conclusion Superselective intra⁃arterial urokinase thrombolysis is probably an effective therapy for sudden vascular deafness. DOI：10.3969/j.issn.1672-6731.2010.02.017

Keywords

• Hearing loss, sudden
• Thrombolytic therapy
• Infusions, intra ⁃ arterial
• Urinary plasminogen activator