Case Report: A case of pediatric persistent refractory ITP responsive to avatrombopag

Antonella Sau; Gianfranco Di Prinzio; Daniela Onofrillo; Anna Caterina Russo; Nicole Santoro; Mauro Di Ianni

doi:10.3389/fimmu.2025.1576053

Frontiers in Immunology (Apr 2025)

Case Report: A case of pediatric persistent refractory ITP responsive to avatrombopag

Antonella Sau,
Gianfranco Di Prinzio,
Daniela Onofrillo,
Anna Caterina Russo,
Nicole Santoro,
Mauro Di Ianni

Affiliations

Antonella Sau: Department of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy
Gianfranco Di Prinzio: Department of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy
Daniela Onofrillo: Department of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy
Anna Caterina Russo: Department of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy
Nicole Santoro: Department of Hematology and Oncology, Santo Spirito Hospital, Pescara, Italy
Mauro Di Ianni: Department of Medicine and Sciences of Aging, G. d’Annunzio University of Chieti and Pescara, Chieti, Italy

DOI: https://doi.org/10.3389/fimmu.2025.1576053
Journal volume & issue: Vol. 16

Abstract

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Immune thrombocytopenia (ITP) is a rare hematologic disorder characterized by low platelet counts due to an immune-mediated destruction of platelets. While corticosteroids, intravenous immunoglobulin (IVIG) are the mainstays of treatment, a subset of patients may remain refractory to these therapies. Here, we present a case of a 6-year-old girl diagnosed with refractory ITP, who failed to respond to standard therapies but showed a remarkable clinical improvement with avatrombopag, a thrombopoietin receptor agonist.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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