Gender Differences in Patients with Gastric Adenocarcinoma

Abstract

Background: Gastric cancer (GC) epidemiology and outcomes vary by gender. Methods: We reviewed 18,436 GC patients from 2008 to 2018 and looked for gender differences in clinical characteristics and survival. Results: The gender proportion was 71% male and 29% female. Males had a significantly (p p p p = 0.0018). The survival advantage for females was evident in the early stages, with a significant difference in localized disease without LNM (p p = 0.0026, log-rank test) but not in the advanced stages. Multivariate Cox regression analysis showed a significantly reduced mortality risk in females (p Conclusions: Significant gender differences exist with regard to pathological type, presentation, clinical stage, and overall survival. These findings suggest gender-specific strategies for screening, diagnosis, and treatment.

Keywords

• gastric cancer
• gender differences
• adenocarcinoma
• retrospective study