Revista do Instituto de Medicina Tropical de São Paulo (Oct 1987)

American trypanosomiasis (Chagas' disease) in conventional and germfree rats and mice

  • Marcelo E. Silva,
  • Elizio A. Evangelista,
  • Jacques R. Nicoli,
  • Eduardo A. Bambirra,
  • Enio C. Vieira

DOI
https://doi.org/10.1590/S0036-46651987000500004
Journal volume & issue
Vol. 29, no. 5
pp. 284 – 288

Abstract

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Germfree (GF) and conventional (CV) CFW (LOB) mice and Wistar and Sprague-Dawley rats were infected with Trypanosoma cruzi. The disease was more severe in the GF than in the CV animals as revealed by: (1) an earlier and more intense parasitemia; (2) a more precocious mortality; (3) a twice enlarged spleen: (4) a more intense cell and tissue parasitism; (5) visceral signs of cardiac failure.

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