Nature Communications (May 2016)

Analytic framework for peptidomics applied to large-scale neuropeptide identification

  • Anna Secher,
  • Christian D. Kelstrup,
  • Kilian W. Conde-Frieboes,
  • Charles Pyke,
  • Kirsten Raun,
  • Birgitte S. Wulff,
  • Jesper V. Olsen

DOI
https://doi.org/10.1038/ncomms11436
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Neuropeptide research is challenged by technical difficulties in identifying new bioactive peptides. Here the authors present an analytical pipeline for large-scale peptidomics applied to the rat hypothalamus, identifying thousands of endogenous neuropeptides and their post-translational modifications.