Nature Communications (Jul 2021)

Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades

  • Alexandro D. Ramirez,
  • Emre R. F. Aksay

DOI
https://doi.org/10.1038/s41467-021-24336-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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The neural mechanisms by which the brain initiates self-generated actions are unclear. The authors show, using population imaging and single-cell ablation, that ramp-to-threshold firing dynamics over multiple seconds is critical for the initiation of self-generated eye movements.