Nature Communications (Nov 2022)
Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models
- Myrofora Panagi,
- Fotios Mpekris,
- Pengwen Chen,
- Chrysovalantis Voutouri,
- Yasuhiro Nakagawa,
- John D. Martin,
- Tetsuro Hiroi,
- Hiroko Hashimoto,
- Philippos Demetriou,
- Chryso Pierides,
- Rekha Samuel,
- Andreas Stylianou,
- Christina Michael,
- Shigeto Fukushima,
- Paraskevi Georgiou,
- Panagiotis Papageorgis,
- Petri Ch. Papaphilippou,
- Laura Koumas,
- Paul Costeas,
- Genichiro Ishii,
- Motohiro Kojima,
- Kazunori Kataoka,
- Horacio Cabral,
- Triantafyllos Stylianopoulos
Affiliations
- Myrofora Panagi
- Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus
- Fotios Mpekris
- Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus
- Pengwen Chen
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- Chrysovalantis Voutouri
- Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus
- Yasuhiro Nakagawa
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- John D. Martin
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- Tetsuro Hiroi
- Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwanoha
- Hiroko Hashimoto
- Division of Innovative Pathology and Laboratory Medicine, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwanoha
- Philippos Demetriou
- The Center for the Study of Hematological and other Malignancies
- Chryso Pierides
- The Center for the Study of Hematological and other Malignancies
- Rekha Samuel
- Center for Stem Cell Research (a unit of inStem Bengaluru), Christian Medical College Campus Bagayam
- Andreas Stylianou
- Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus
- Christina Michael
- Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus
- Shigeto Fukushima
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- Paraskevi Georgiou
- Basic and Translational Cancer Research Center, School of Sciences, European University of Cyprus
- Panagiotis Papageorgis
- Basic and Translational Cancer Research Center, School of Sciences, European University of Cyprus
- Petri Ch. Papaphilippou
- Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus
- Laura Koumas
- The Center for the Study of Hematological and other Malignancies
- Paul Costeas
- The Center for the Study of Hematological and other Malignancies
- Genichiro Ishii
- Division of Innovative Pathology and Laboratory Medicine, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwanoha
- Motohiro Kojima
- Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwanoha
- Kazunori Kataoka
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- Horacio Cabral
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- Triantafyllos Stylianopoulos
- Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus
- DOI
- https://doi.org/10.1038/s41467-022-34744-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Nanotherapy has potential utility in cancer, particularly in targeted delivery of therapeutics. Here the authors demonstrate delivery of tranilast loaded micelles to improve the reprogramming of cancer associated fibroblasts and monitor tumour stiffness to predict responses.
