Nature Communications (Feb 2018)
ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity
Abstract
The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of neutrophils.