Nature Communications (Feb 2018)

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

  • Matteo Massara,
  • Ornella Bonavita,
  • Benedetta Savino,
  • Nicoletta Caronni,
  • Valeria Mollica Poeta,
  • Marina Sironi,
  • Elisa Setten,
  • Camilla Recordati,
  • Laura Crisafulli,
  • Francesca Ficara,
  • Alberto Mantovani,
  • Massimo Locati,
  • Raffaella Bonecchi

DOI
https://doi.org/10.1038/s41467-018-03080-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of neutrophils.