Nature Communications (Jun 2019)

NIR-light-mediated spatially selective triggering of anti-tumor immunity via upconversion nanoparticle-based immunodevices

  • Hongqian Chu,
  • Jian Zhao,
  • Yongsheng Mi,
  • Zhenghan Di,
  • Lele Li

DOI
https://doi.org/10.1038/s41467-019-10847-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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The use of immunotherapy can be limited by adverse side effects. In this study, the authors designed a nanodevice that spatiotemporally controlled activate immunomodulatory agents at the tumour site upon near-infrared light triggering, thus preventing systemic toxicity with maintained efficacy